Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of peri-implant lesion

Author:

Xia Yiru12,Zhang Zhaowenbin345,Zhou Kecong12,Lin Zhikai12,Shu Rong12,Xu Yuze345,Zeng Zhen3456,Chang Jiang345ORCID,Xie Yufeng1278

Affiliation:

1. Department of Periodontology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China

2. College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai , China

3. Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou 325000, China

4. Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences , Wenzhou 325000, China

5. State Key Laboratory of High-Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , Shanghai 200050, China

6. Key Laboratory of Rehabilitation Medicine in Sichuan Province, West China Hospital, Sichuan University , Chengdu, China

7. Department of Periodontology, Shanghai Stomatological Hospital & School of Stomatology, Fudan University , Shanghai, China

8. Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University , Shanghai, China

Abstract

Abstract Peri-implant lesion is a grave condition afflicting numerous indi-viduals with dental implants. It results from persistent periodontal bacteria accumulation causing inflammation around the implant site, which can primarily lead to implant loosening and ultimately the implant loss. Early-stage peri-implant lesions exhibit symptoms akin to gum disease, including swelling, redness and bleeding of the gums surrounding the implant. These signs indicate infection and inflammation of the peri-implant tissues, which may result in bone loss and implant failure. To address this problem, a thermionic strategy was applied by designing a cuprorivaite–hardystonite bioceramic/alginate composite hydrogel with photothermal and Cu/Zn/Si multiple ions releasing property. This innovative approach creates a thermionic effect by the release of bioactive ions (Cu2+ and Zn2+ and SiO32−) from the composite hydrogel and the mild heat environment though the photothermal effect of the composite hydrogel induced by near-infrared light irradiation. The most distinctive advantage of this thermionic effect is to substantially eliminate periodontal pathogenic bacteria and inhibit inflammation, while simultaneously enhance peri-implant osseointegration. This unique attribute renders the use of this composite hydrogel highly effective in significantly improving the survival rate of implants after intervention in peri-implant lesions, which is a clinical challenge in periodontics. This study reveals application potential of a new biomaterial-based approach for peri-implant lesion, as it not only eliminates the infection and inflammation, but also enhances the osteointegration of the dental implant, which provides theoretical insights and practical guidance to prevent and manage early-stage peri-implant lesion using bioactive functional materials.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Reference54 articles.

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