Loss of Full-Length GATA1 Expression in Megakaryocytes Is a Sensitive and Specific Immunohistochemical Marker for the Diagnosis of Myeloid Proliferative Disorder Related to Down Syndrome

Author:

Lee Winston Y1,Weinberg Olga K12,Evans Andrew G3,Pinkus Geraldine S1

Affiliation:

1. Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

2. Department of Pathology, Boston Children’s Hospital, Boston, MA

3. Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Reference27 articles.

1. The biology of pediatric acute megakaryoblastic leukemia;Gruber;Blood,2015

2. Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis;Roy;Br J Haematol,2009

3. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia;Arber;Blood,2016

4. Immunophenotype of Down syndrome acute myeloid leukemia and transient myeloproliferative disease differs significantly from other diseases with morphologically identical or similar blasts;Langebrake;Klin Padiatr,2005

5. Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome: an immunophenotypic analysis;Karandikar;Am J Clin Pathol,2001

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