Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine

Author:

Faller Kiterie M E1,Atzler Dorothee123,McAndrew Debra J1,Zervou Sevasti1,Whittington Hannah J1,Simon Jillian N1,Aksentijevic Dunja1,ten Hove Michiel1,Choe Chi-un4,Isbrandt Dirk56,Casadei Barbara1,Schneider Jurgen E17,Neubauer Stefan1,Lygate Craig A1

Affiliation:

1. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, BHF Centre of Research Excellence at the University of Oxford and the Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford OX3 7BN, UK;

2. German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Institute for Cardiovascular Prevention (IPEK), Pettenkoferstraße 8a & 9, 80336 Munich, Germany;

3. Walther-Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University, Goethestrasse 33, 80336 Munich, Germany;

4. Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany;

5. Experimental Neurophysiology, German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany;

6. The Institute for Molecular and Behavioral Neuroscience, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany;

7. Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, LS2 9JT, UK

Funder

Wellcome Trust

British Heart Foundation

Deutsche Forschungsgemeinschaft

DFG

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

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