Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study-Reference-Cited by-同舟云学术

Clonal Patterns Between Pouch Neoplasia and Prior Colorectal Neoplasia in Inflammatory Bowel Disease Patients: An Exploratory Cohort Study

Published:2023-06-16 Issue:8 Volume:29 Page:1347-1351
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

te Groen Maarten¹^ORCID,Derikx Lauranne A A P¹²,van Lierop Lisa¹,Ylstra Bauke³^ORCID,Hoentjen Frank¹⁴,Nagtegaal Iris D⁵,Simmer Femke⁵

Affiliation:

1. Department of Gastroenterology, Radboud University Medical Center , Nijmegen , the Netherlands

2. Department of Gastroenterology, Erasmus Medical Center , Rotterdam , the Netherlands

3. Department of Pathology, Amsterdam University Medical Centers , Amsterdam , the Netherlands

4. Division of Gastroenterology, Department of Medicine, University of Alberta , Edmonton, Alberta , Canada

5. Department of Pathology, Radboud University Medical Center , Nijmegen , the Netherlands

Abstract

Lay Summary Prior colorectal neoplasia is the strongest predictor of pouch neoplasia in inflammatory bowel disease, but the underlying mechanism is unknown. We observed clonality between colorectal and pouch neoplasia in 30% of patients, indicating that most pouch neoplasia develops clonally independent from prior colorectal lesions.

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izad112/50629103/izad112.pdf

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