Lack of Seroconversion Following COVID-19 Vaccination Is an Independent Risk Factor for SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: Data from ESCAPE-IBD, an IG-IBD Study-Reference-Cited by-同舟云学术

Lack of Seroconversion Following COVID-19 Vaccination Is an Independent Risk Factor for SARS-CoV-2 Infection in Patients With Inflammatory Bowel Disease: Data from ESCAPE-IBD, an IG-IBD Study

Published:2023-06-30 Issue: Volume: Page:
ISSN:1078-0998
Container-title:Inflammatory Bowel Diseases
language:en
Short-container-title:

Author:

Macaluso Fabio Salvatore¹^ORCID,Principi Mariabeatrice²,Facciotti Federica³,Contaldo Antonella⁴,Todeschini Alessia⁵,Saibeni Simone⁶^ORCID,Bezzio Cristina⁶,Castiglione Fabiana⁷,Nardone Olga Maria⁷,Spagnuolo Rocco⁸⁹,Fantini Massimo Claudio¹⁰,Riguccio Gaia¹¹,Conforti Simone¹²¹³,Caprioli Flavio¹²¹³,Viganò Chiara¹⁴,Felice Carla¹⁵,Fiorino Gionata¹⁶^ORCID,Correale Carmen¹⁷,Bodini Giorgia¹⁸,Milla Monica¹⁹,Scardino Giulia²⁰,Vernero Marta²¹,Desideri Federico²²,Bossa Fabrizio²³,Guerra Maria²³,Ventimiglia Marco²⁴,Casà Angelo¹,Rizzo Giuseppe¹,Orlando Ambrogio¹,Amato Arnaldo,Ascolani Marta,Calabrese Giulio,Comberlato Michele,De Bona Manuela,Demarzo Maria Giulia,Doldo Patrizia,Dragoni Gabriele,Furfaro Federica,Laffusa Alice,Martino Giuseppina,Mulinacci Giacomo,Olmo Oriana,O’Sed Nicole Piazza,Paba Salvatore,Radice Simona,Renna Sara,Ribaldone Davide Giuseppe,

Affiliation:

1. IBD Unit, “Villa Sofia-Cervello” Hospital , Palermo , Italy

2. Gastroenterology Department, “Aldo Moro” University , Bari , Italy

3. Istituto Europeo di Oncologia IRCCS, Dipartimento di Oncologia Sperimentale , Milan , Italy

4. Gastroenterology 2 Unit, IRCCS “S. De Bellis” , Castellana Grotte, Bari , Italy

5. IBD Unit, IRCCS Sacro Cuore Don Calabria , Negrar di Valpolicella, Verona , Italy

6. Gastroenterology Unit, Rho Hospital, ASST Rhodense , Rho, Milan , Italy

7. Dipartimento di Medicina Clinica e Chirurgia, Università Federico II di Napoli, Naples, Italy

8. U.O. Gastroenterologia ed Endoscopia Digestiva , A.O.U. “Mater Domini,” Catanzaro , Italy

9. Dipartimento di Medicina Sperimentale e Clinica, Università “Magna Graecia” Catanzaro , Italy

10. AOU Policlinico Monserrato, Dipartimento di Scienze Mediche e Sanità Pubblica, Università di Cagliari , Italy

11. UOSD Malattie Infiammatorie Croniche intestinali, Ospedale Santa Maria del Prato , Feltre , Italy

12. Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico di Milano , Italy

13. Department of Pathophysiology and Transplantation, Università degli Studi di Milano , Milan , Italy

14. Division of Gastroenterology and Center for Autoimmune Liver Diseases, Department of Medicine and Surgery, University of Milano-Bicocca , Monza , Italy

15. UOC Gastroenterologia , Ospedale Ca’Foncello, Treviso , Italy

16. Dipartimento di Gastroenterologia ed Endoscopia Digestiva, IRCCS Ospedale San Raffaele e Università Vita-Salute San Raffaele , Milano , Italia

17. Humanitas Clinical and Research Center – IRCCS , Rozzano , Italy

18. IRCCS Policlinico San Martino, Università di Genova , Italy

19. IBD Referral Center, Gastroenterology Unit, Azienda Ospedaliero-Universitaria Careggi , Florence , Italy

20. Dipartimento di Gastroenterologia , Ospedale Valduce, Como , Italy

21. Gastroenterology Unit, Department of Medical Sciences, University of Pavia , Pavia , Italy

22. Gastroenterology Department, San Maurizio Hospital , Bolzano , Italy

23. Division of Gastroenterology, “Casa Sollievo della Sofferenza” Hospital, IRCCS , San Giovanni Rotondo , Italy

24. Directorate General of Medical Device and Pharmaceutical Service; Italian Ministry of Health , Rome , Italy

Abstract

This prospective study reported 2 key results: (1) lack of seroconversion following 2 doses of COVID-19 vaccines is an independent predictor of SARS-CoV-2 infection; (2) treatments for IBD were not associated with increased risk of SARS-CoV-2 infection.

Funder

AMICI Onlus

Italian Inflammatory Bowel Disease patients’ association

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

Link

https://academic.oup.com/ibdjournal/advance-article-pdf/doi/10.1093/ibd/izad118/50768502/izad118.pdf

Reference11 articles.

1. Vaccinations in patients with inflammatory bowel disease;Macaluso;Dig Liver Dis,2021

2. Effectiveness and safety of SARS-CoV-2 vaccine in Inflammatory Bowel Disease patients: a systematic review, meta-analysis and meta-regression;Bhurwal;Aliment Pharmacol Ther,2022

3. COVID-19 vaccination among individuals with inflammatory bowel disease: perception, efficacy, and safety;Weaver;Gastroenterol Hepatol (N Y),2022

4. Neutralising antibody potency against SARS-CoV-2 wild-type and omicron BA.1 and BA.4/5 variants in patients with inflammatory bowel disease treated with infliximab and vedolizumab after three doses of COVID-19 vaccine (CLARITY IBD): an analysis of a prospective multicentre cohort study.;Liu;Lancet Gastroenterol Hepatol,2023

5. Vaccine escape, increased breakthrough and reinfection in infliximab-treated patients with IBD during the Omicron wave of the SARS-CoV-2 pandemic.;Kennedy;Gut,2023