Postvaccination Symptoms After a Fourth Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease

Author:

Lee Yoo Jin12ORCID,Li Dalin1,Mujukian Angela1,Debbas Philip1,Hampton Melissa1,Mengesha Emebet1,Cheng Susan3,Ebinger Joseph E3,Chiorean Michael4,Lum Donald5,Damas Oriana M6,Braun Jonathan1ORCID,McGovern Dermot P B1,Melmed Gil Y1ORCID,Banty Andrea7,Feldman Edward7,Ha Christina7,Lee Susie7,Rabizadeh Shervin7,Stein Theodore7,Solomon Theodore7,Syal Gaurav7,Targan Stephan7,Vasiliauskas Eric7,Ziring David7,Bonthala Niru7,Botwin Gregory S7,Hampton Melissa7,Mengesha Emebet7,Khanishian Elizabeth7,Pozdnyakova Valeriya7,Gu Phillip7,White Shane7,Zamudio Cindy7,Gonzalez Daniel7,Parry Alyssa7,Hanna Mary7,Chan Justin7,Ebinger Joe8,Joung Sandy8,Wu Min8,Hoang Amy8,Wynter Timothy8,Sun Nancy8,Figueiredo Jane C9,Merchant Akil9,Merin Noah9,Reckamp Karen L9,Appel Keren10,Kumar Rashmi11,Boland Brigid12,Charabaty Aline13,Chiorean Michael14,Cohen Erica15,Flynn Ann16,Valentine John16,Ehrlich Adam C17,Fudman David18,Horizon Arash19,Karayev Dmitry19,Kretzmann Benjamin19,Hou Jason20,Hwang Caroline21,Lazarev Mark22,Lum Donald23,Fausel Rebecca23,Reddy Swapna23,McConnell Ryan24,Mattar Mark C25,Metwally Mark26,Ostrov Arthur26,Parekh Nimisha27,Raffals Laura28,Rubin David T29,Sheibani Sarah30,Siegel Corey A31,Wolf Douglas32,Younes Ziad33,

Affiliation:

1. F. Widjaja Inflammatory Bowel Disease Institute, Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center , Los Angeles, CA , USA

2. Department of Internal Medicine, Keimyung University School of Medicine , Daegu , Republic of Korea

3. Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Smidt Heart Institute, Cedars-Sinai Medical Center , Los Angeles, CA , USA

4. Swedish Medical Group , Seattle, Washington , USA

5. The Oregon Clinic , Portland, Oregon , USA

6. Division of Gastroenterology, Miller School of Medicine, University of Miami , Miami, Florida , USA

7. Inflammatory Bowel and Immunobiology Research Institute, Karsh Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

8. Smidt Heart Institute, Department of Medicine, Cedars-Sinai, Los Angeles, CA, USA

9. Samual Oschin Comprehensive Cancer Institute, Cedars-Sinai, Los Angeles, CA, USA

10. Children’s Hospital, Orange County, CA, USA

11. Banner University Medical Center, Phoenix, AZ, USA

12. University of California, San Diego, CA, USA

13. Sibley Memorial Hospital, Johns Hopkins, Washington, DC, USA

14. Swedish Medical Center, Seattle, WA, USA

15. Capital Digestive Care, Chevy Chase, MD, USA

16. University of Utah, Salt Lake City, UT, USA

17. Temple University, Philadelphia, PA, USA

18. UT Southwestern, Dallas, TX, USA

19. Center for Rheumatology, Los Angeles, CA, USA

20. Baylor College of Medicine, Houston, TX, USA

21. Hoag Hospital, Newport Beach, CA, USA

22. Johns Hopkins Hospital, Baltimore, MD, USA

23. The Oregon Clinic, Portland, OR, USA

24. Sutter Health, Palo Alto, CA, USA

25. Medstar-Georgetown, Washington, DC, USA

26. Saratoga-Schenectady Gastroenterology, Saratoga Springs, NY, USA

27. University of California, Irvine, CA, USA

28. The Mayo Clinic, Rochester, MN, USA

29. University of Chicago, Chicago, IL, USA

30. Keck Medicine of University of Southern California, Los Angeles, CA, USA

31. Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA

32. Atlanta Gastroenterology Associates, Atlanta, GA, USA

33. Gastro One, Germantown, TN, USA

Abstract

Overall, 1933 participants with IBD completed at least 1 questionnaire regarding postvaccination symptoms after administration of each of the 4 mRNA SARS-CoV-2 vaccine doses. Symptoms after a fourth mRNA vaccine are less frequent and generally milder than after previous doses.

Funder

National Institute of Diabetes and Digestive and Kidney Disease

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology,Immunology and Allergy

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