Pharmacological serum concentrations of epinephrine and norepinephrine do not affect growth rate, morphogenesis, stress tolerance, and virulence of Candida albicans

Author:

Wurster Sebastian1,Lyos Sebastian12,Albert Nathaniel D1,Kontoyiannis Dimitrios P1

Affiliation:

1. Department of Infectious Diseases, Infection Control and Employee Health; The University of Texas M.D. Anderson Cancer Center; Houston, Texas, USA

2. College of Literature, Sciences and the Arts; University of Michigan; Ann Arbor, Michigan, USA

Abstract

Abstract Vasopressors are frequently given in hemodynamically unstable patients with severe Candida sepsis. While catecholamines can aggravate sepsis-induced immune dysfunction and modulate bacterial virulence traits, their impact on fungal pathogenicity is poorly understood. Using IncuCyte time-lapse microscopy and a fruit fly candidiasis model, we studied growth rates, morphogenesis, stress tolerance, and virulence of C. albicans cocultured with epinephrine and norepinephrine. We found that pharmacologically attainable catecholamine serum concentrations caused minimal changes to in vitro growth kinetics, filamentation, and fungal resistance to thermal or oxidative stress. Similarly, exposure of C. albicans to catecholamines did not alter the survival of infected flies.

Funder

NIH-NCI Cancer Center CORE

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,General Medicine

Reference20 articles.

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4. Influences of stress hormones on microbial infections;Sarkodie;Microb Pathog,2019

5. Dopamine, morphine, and nitric oxide: an evolutionary signaling triad;Stefano;CNS Neurosci Ther,2010

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