Loss of MeCP2 in immature neurons leads to impaired network integration

Author:

Sun Yi123,Gao Yu34,Tidei Joseph J34,Shen Minjie34,Hoang Johnson T34,Wagner Daniel F34,Zhao Xinyu345ORCID

Affiliation:

1. National Key Research Laboratory of Natural and Biomimetic Drugs

2. Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking University, Beijing, PR China

3. Waisman Center

4. Department of Neuroscience

5. Cellular and Molecular Biology Program, University of Wisconsin–Madison, Madison, WI, USA

Funder

National Institutes of Health

Waisman Center

International Rett Syndrome Foundation

Brain Research Foundation

UW Vilas Trust

Wisconsin Alumni Research Foundation

Jenni and Kyle Professorship

China Scholarship Council

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference58 articles.

1. Clinical and biological progress over 50 years in Rett syndrome;Leonard;Nat. Rev. Neurol.,2017

2. DNA methylation and adult neurogenesis;Jobe;Brain Plast.,2017

3. Delayed maturation of neuronal architecture and synaptogenesis in cerebral cortex of Mecp2-deficient mice;Fukuda;J. Neuropathol. Exp. Neurol.,2005

4. Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons;Smrt;Neurobiol. Dis.,2007

5. MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively;Palmer;Mol. Cell. Neurosci.,2008

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