Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans

Author:

Polfus Linda M1ORCID,Raffield Laura M2,Wheeler Marsha M3,Tracy Russell P45,Lange Leslie A6,Lettre Guillaume78,Miller Amanda9,Correa Adolfo10,Bowler Russell P11,Bis Joshua C12,Salimi Shabnam13,Jenny Nancy Swords4,Pankratz Nathan14ORCID,Wang Biqi15,Preuss Michael H1617,Zhou Lisheng16,Moscati Arden16,Nadkarni Girish N16,Loos Ruth J F161718,Zhong Xue19,Li Bingshan19,Johnsen Jill M2021,Nickerson Deborah A3,Reiner Alex P2223,Auer Paul L9,

Affiliation:

1. Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

2. Department of Genetics, University of North Carolina, Chapel Hill, NC, USA

3. Department of Genome Sciences, University of Washington Center for Mendelian Genomics, Seattle, WA, USA

4. Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, USA

5. Department of Biochemistry, Larner College of Medicine, University of Vermont, Burlington, VT, USA

6. Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA

7. Department of Medicine, Université de Montréal, Montréal, QC, Canada

8. Montreal Heart Institute, Montréal, QC, Canada

9. Zilber School of Public Health, University of Wisconsin–Milwaukee, Milwaukee, WI, USA

10. Department of Pediatrics and Medicine, University of Mississippi Medical Center, Jackson, MS, USA

11. Department of Medicine, National Jewish Health, Denver, CO, USA

12. Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA

13. School of Medicine, University of Maryland, Baltimore, MD, USA

14. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA

15. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA

16. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

17. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA

18. Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

19. Vanderbilt Genetics Institute, Nashville, TN, USA

20. Bloodworks Northwest Research Institute, Seattle, WA, USA

21. Department of Medicine, University of Washington, Seattle, WA, USA

22. Department of Epidemiology, University of Washington, Seattle, WA, USA

23. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

Funder

National Heart, Lung, and Blood Institute

Jackson Heart Study

University of Washington

TOPMed Informatics Research Center

TOPMed Data Coordination Center

Jackson State University

Tougaloo College

University of Mississippi

National Institute on Minority Health and Health Disparities

Women's Health Initiative

U.S. Department of Health and Human Services

Andrea and Charles Bronfman Philanthropies

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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