Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length

Author:

Laisk Triin123,Kukuškina Viktorija2,Palmer Duncan45,Laber Samantha67,Chen Chia-Yen489,Ferreira Teresa6,Rahmioglu Nilufer7,Zondervan Krina710,Becker Christian10,Smoller Jordan W58,Lippincott Margaret11,Salumets Andres131213,Granne Ingrid14,Seminara Stephanie11,Neale Benjamin48,Mägi Reedik2,Lindgren Cecilia M6715

Affiliation:

1. Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia

2. Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia

3. Competence Centre on Health Technologies, Tartu, Estonia

4. Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA

5. Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA

6. Big Data Institute, Li Ka Shing Center for Health for Health Information and Discovery, Oxford University, Oxford, UK

7. Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK

8. Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA

9. Broad Institute of MIT and Harvard, Boston, Massachusetts, USA

10. Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s and Reproductive Health, University of Oxford, UK

11. Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA

12. Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

13. Department of Biomedicine, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia

14. Nuffield Department of Women’s and Reproductive Health, University of Oxford, UK

15. Program in Medical and Population Genetics, Broad Institute, Boston, MA, USA

Funder

European Commission

Ministry of Education and Research

Enterprise Estonia

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institutes of Health

Novo Nordisk

National Institute for Health Research

Biomedical Research Foundation

Li Ka Shing Foundation

John Fell Fund, University of Oxford

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Reference56 articles.

1. Endocrine regulation of menstruation;Jabbour;Endocr. Rev.,2006

2. Modeling menstrual cycle length using a mixture distribution;Guo;Biostatistics,2006

3. The normal menstrual cycle and the control of ovulation;Reed,2018

4. The endocrinology of the menstrual cycle;Barbieri;Methods Mol. Biol.,2014

5. Menstrual cycle characteristics: associations with fertility and spontaneous abortion;Small;Epidemiology,2006

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