Admixture mapping identifies novel loci for obstructive sleep apnea in Hispanic/Latino Americans

Author:

Wang Heming1234,Cade Brian E234,Sofer Tamar235,Sands Scott A23,Chen Han67,Browning Sharon R5,Stilp Adrienne M5,Louie Tin L5,Thornton Timothy A5,Johnson W Craig5,Below Jennifer E8,Conomos Matthew P5,Evans Daniel S9,Gharib Sina A10,Guo Xiuqing11,Wood Alexis C12,Mei Hao13,Yaffe Kristine1415,Loredo Jose S16,Ramos Alberto R17,Barrett-Connor Elizabeth18,Ancoli-Israel Sonia1920,Zee Phyllis C21,Arens Raanan22,Shah Neomi A23,Taylor Kent D11,Tranah Gregory J9,Stone Katie L9,Hanis Craig L6,Wilson James G24,Gottlieb Daniel J2325,Patel Sanjay R26,Rice Ken5,Post Wendy S27,Rotter Jerome I11,Sunyaev Shamil R42829,Cai Jianwen30,Lin Xihong31,Purcell Shaun M2432,Laurie Cathy C5,Saxena Richa23433,Redline Susan2334,Zhu Xiaofeng1

Affiliation:

1. Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA

2. Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, Boston, MA , USA

3. Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA

4. Broad Institute, Cambridge, MA 02142, USA

5. Department of Biostatistics, University of Washington, Seattle, WA, USA

6. Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA

7. Center for Precision Health, School of Public Health & School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA

8. Vanderbilt Genetics Institute, Department of Medical Genetics, Vanderbilt University Medical Center, Nashville, TN, USA

9. California Pacific Medical Center Research Institute, San Francisco, CA, USA

10. Computational Medicine Core, Center for Lung Biology, UW Medicine Sleep Center, Division of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, WA, USA

11. Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center, Torrance, CA, USA

12. USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA

13. Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA

14. Departments of Psychiatry and Neurology, University of California, San Francisco, San Francisco, CA, USA

15. Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA

16. Division of Pulmonary Critical Care and Sleep Medicine, Department of Medicine, UC San Diego School of Medicine, La Jolla, CA, USA

17. Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA

18. Department of Family and Preventive Medicine, University of California, San Diego, CA, USA

19. Departments of Medicine and Psychiatry, University of California, San Diego, CA, USA

20. Department of Veterans Affairs, San Diego Center of Excellence for Stress and Mental Health, San Diego, CA, USA

21. Department of Neurology and Sleep Medicine Center, Northwestern University, Chicago, IL, USA

22. The Children’s Hospital at Montefiore, Division of Respiratory and Sleep Medicine, Albert Einstein College of Medicine, Bronx, NY, USA

23. Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA

24. Physiology and Biophysics, University of Mississippi, Jackson, MS, USA

25. VA Boston Healthcare System, Boston, MA, USA

26. Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

27. Division of Cardiology, Johns Hopkins University, Baltimore, MD, USA

28. Division of Genetics, Brigham and Women’s Hospital, Boston, MA, USA

29. Division of Medical Sciences, Harvard Medical School, Boston, MA, USA

30. Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA

31. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA

32. Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

33. Center for Genomic Medicine and Department of Anesthesia, Pain, and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA

34. Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA

Funder

National Institutes of Health

National Heart, Lung, and Blood Institute

National Human Genome Research Institute

Sleep Research Society Foundation

American Thoracic Society

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

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