Repeat hepatic resection versus radiofrequency ablation for recurrent hepatocellular carcinoma: retrospective multicentre study-Reference-Cited by-同舟云学术

Repeat hepatic resection versus radiofrequency ablation for recurrent hepatocellular carcinoma: retrospective multicentre study

Published:2021-10-13 Issue:1 Volume:109 Page:71-78
ISSN:0007-1323
Container-title:British Journal of Surgery
language:en
Short-container-title:

Author:

Zhong J -H¹^ORCID,Xing B -C²,Zhang W -G³,Chan A W -H⁴,Chong C C N⁵^ORCID,Serenari M⁶,Peng N⁷,Huang T⁸,Lu S -D⁹,Liang Z -Y¹⁰,Huo R -R¹,Wang Y -Y²,Cescon M⁶,Liu T -Q⁸,Li L⁹,Wu F -X¹,Ma L¹,Ravaioli M⁶,Neri J⁶,Cucchetti A⁶,Johnson P J¹¹,Li L -Q¹,Xiang B -D¹

Affiliation:

1. Hepatobiliary Surgery Department, Guangxi Liver Cancer Diagnosis and Treatment Engineering and Technology Research Centre, Guangxi Medical University Cancer Hospital, Nanning, China

2. Hepatopancreatobiliary Surgery Department I, Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, China

3. Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

4. State Key Laboratory in Oncology in South China, Sir Y. K. Pao Centre for Cancer, Department of Anatomical & Cellular Pathology, and Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China

5. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

6. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy

7. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China

8. Department of Hepatobiliary Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China

9. Department of Hepatobiliary Surgery, The Third Affiliated Hospital of Guangxi Medical University, Nanning, China

10. Department of Hepatobiliary Surgery, The First People’s Hospital of Nanning, Nanning, China

11. Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK

Abstract

Abstract Background The therapeutic value of repeat hepatic resection (rHR) or radiofrequency ablation (RFA) for recurrent hepatocellular carcinoma (HCC) is unknown. This study aimed to investigate the safety and efficacy of rHR or RFA. Methods This was a retrospective multicentre study of patients with recurrent HCC within the Milan criteria who underwent rHR or RFA at nine university hospitals in China and Italy between January 2003 and January 2018. Survival after rHR or RFA was examined in unadjusted analyses and after propensity score matching (1 : 1). Results Of 847 patients included, 307 and 540 underwent rHR and RFA respectively. Median overall survival was 73.5 and 67.0 months after rHR and RFA respectively (hazard ratio 1.01 (95 per cent c.i. 0.81 to 1.26)). Median recurrence-free survival was longer after rHR versus RFA (23.6 versus 15.2 months; hazard ratio 0.76 (95 per cent c.i. 0.65 to 0.89)). These results were confirmed after propensity score matching. RFA was associated with lower morbidity of grade 3 and above (0.6 versus 6.2 per cent; P < 0.001) and shorter hospital stay (8.0 versus 3.0 days, P < 0.001) than rHR. Conclusion rHR was associated with longer recurrence-free survival but not overall survival compared with RFA.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Guangxi BaGui Scholars’ Special Fund

Guangxi Natural Science Foundation

Science Research and Technology Development Programme of Guangxi

Colleges and Universities

Publisher

Oxford University Press (OUP)

Subject

Surgery

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