Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function

Author:

Chasman Daniel I.12,Fuchsberger Christian3,Pattaro Cristian4,Teumer Alexander5,Böger Carsten A.6,Endlich Karlhans7,Olden Matthias68,Chen Ming-Huei910,Tin Adrienne11,Taliun Daniel4,Li Man11,Gao Xiaoyi12,Gorski Mathias813,Yang Qiong10,Hundertmark Claudia14,Foster Meredith C.15,O'Seaghdha Conall M.216,Glazer Nicole17,Isaacs Aaron1819,Liu Ching-Ti20,Smith Albert V.2122,O'Connell Jeffrey R.23,Struchalin Maksim24,Tanaka Toshiko25,Li Guo26,Johnson Andrew D.15,Gierman Hinco J.27,Feitosa Mary F.12,Hwang Shih-Jen15,Atkinson Elizabeth J.28,Lohman Kurt29,Cornelis Marilyn C.30,Johansson Åsa31,Tönjes Anke32,Dehghan Abbas18,Lambert Jean-Charles33,Holliday Elizabeth G.34,Sorice Rossella35,Kutalik Zoltan3637,Lehtimäki Terho38,Esko Tõnu3940,Deshmukh Harshal41,Ulivi Sheila42,Chu Audrey Y.1,Murgia Federico43,Trompet Stella44,Imboden Medea4546,Coassin Stefan47,Pistis Giorgio48,Harris Tamara B.49,Launer Lenore J.49,Aspelund Thor2122,Eiriksdottir Gudny21,Mitchell Braxton D.23,Boerwinkle Eric50,Schmidt Helena51,Cavalieri Margherita51,Rao Madhumathi52,Hu Frank30,Demirkan Ayse1819,Oostra Ben A.1819,de Andrade Mariza28,Turner Stephen T.53,Ding Jingzhong54,Andrews Jeanette S.55,Freedman Barry I.54,Giulianini Franco1,Koenig Wolfgang56,Illig Thomas13,Meisinger Christa57,Gieger Christian57,Zgaga Lina5859,Zemunik Tatijana60,Boban Mladen60,Minelli Cosetta4,Wheeler Heather E.2761,Igl Wilmar31,Zaboli Ghazal31,Wild Sarah H.58,Wright Alan F.62,Campbell Harry58,Ellinghaus David63,Nöthlings Ute64,Jacobs Gunnar64,Biffar Reiner65,Ernst Florian47,Homuth Georg5,Kroemer Heyo K.66,Nauck Matthias67,Stracke Sylvia68,Völker Uwe5,Völzke Henry69,Kovacs Peter32,Stumvoll Michael32,Mägi Reedik407071,Hofman Albert18,Uitterlinden Andre G.72,Rivadeneira Fernando72,Aulchenko Yurii S.18,Polasek Ozren60,Hastie Nick62,Vitart Veronique62,Helmer Catherine73,Wang Jie Jin7475,Stengel Bénédicte76,Ruggiero Daniela35,Bergmann Sven37,Kähönen Mika77,Viikari Jorma78,Nikopensius Tiit39,Province Michael12,Ketkar Shamika12,Colhoun Helen41,Doney Alex41,Robino Antonietta4279,Krämer Bernhard K.80,Portas Laura43,Ford Ian81,Buckley Brendan M.82,Adam Martin45,Thun Gian-Andri45,Paulweber Bernhard83,Haun Margot47,Sala Cinzia48,Mitchell Paul74,Ciullo Marina35,Kim Stuart K.61,Vollenweider Peter84,Raitakari Olli78,Metspalu Andres3940,Palmer Colin85,Gasparini Paolo4279,Pirastu Mario43,Jukema J. Wouter868788,Probst-Hensch Nicole M.4546,Kronenberg Florian47,Toniolo Daniela48,Gudnason Vilmundur2122,Shuldiner Alan R.2389,Coresh Josef1190,Schmidt Reinhold91,Ferrucci Luigi25,Siscovick David S.26,van Duijn Cornelia M.18,Borecki Ingrid B.12,Kardia Sharon L.R.92,Liu Yongmei29,Curhan Gary C.293,Rudan Igor58,Gyllensten Ulf31,Wilson James F.58,Franke Andre63,Pramstaller Peter P.4,Rettig Rainer94,Prokopenko Inga7071,Witteman Jacqueline18,Hayward Caroline62,Ridker Paul M12,Parsa Afshin95,Bochud Murielle96,Heid Iris M.813,Kao W.H. Linda1190,Fox Caroline S.21597,Köttgen Anna1411, , , ,

Affiliation:

1. Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, Boston, MA 02215, USA,

2. Harvard Medical School, Boston, MA 02115, USA,

3. Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA,

4. Center for Biomedicine, European Academy of Bozen/Bolzano, Affiliated Institute of the University of Lübeck, Germany, Viale Druso, 1-39100 Bolzano, Italy,

5. Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald, Germany,

6. Department of Internal Medicine II and

7. Institute of Anatomy and Cell Biology, University of Greifswald, Friedrich-Loeffler-Str. 23c, 17487 Greifswald, Germany,

8. Department of Epidemiology and Preventive Medicine, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93042 Regensburg, Germany

9. Department of Neurology, Boston University School of Medicine, 72 East Concord St. B603, Boston, MA 02118, USA,

10. Department of Biostatistics, Boston University School of Public Health, 715 Albany St., Boston, MA 02118, USA,

11. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD 21205, USA,

12. Division of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Blvd. Box 8506, St Louis, MO 63108, USA,

13. Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany,

14. Renal Division, Freiburg University Clinic, Berliner Allee 29, 79110 Freiburg, Germany,

15. Center for Population Studies, NHLBI Framingham Heart Study, 73 Mt Wayte Ave Suite #2, Framingham, MA 01702, USA,

16. Division of Nephrology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, USA,

17. Section of Preventive Medicine and Epidemiology, Department of Medicine, Boston University School of Medicine, 761 Harrison Ave, Boston, MA 02118, USA,

18. Department of Epidemiology, Erasmus Medical Center, Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam, The Netherlands,

19. Centre for Medical Systems Biology, Leiden University, Leiden, The Netherlands,

20. Department of Biostatistics, Boston University School of Public Health, 801 Massachusetts Ave, CT3, Boston, MA 02118, USA,

21. Icelandic Heart Association, Research Institute, Holtasmari 1, 201 Kopavogur, Iceland,

22. University of Iceland, Sæmundargötu 2, 101 Reykjavik, Iceland,

23. Department of Medicine and

24. Departments of Epidemiology and Biostatistics, and Forensic Molecular Biology, University of Rotterdam, Dr Molewaterplein 50-603015, Rotterdam, GE, The Netherlands,

25. Clinical Research Branch, National Institute of Aging, 3001 S Hanover Street, Baltimore, MD 21225, USA,

26. University of Washington, 1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448, USA,

27. Department of Developmental Biology, Stanford University, Stanford, CA 94305, USA and

28. Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA and

29. Department of Epidemiology and Prevention, Public Health Sciences,

30. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 2, Boston, MA 02115, USA,

31. Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE-751 85 Uppsala, Sweden,

32. IFB Adiposity Diseases and Department of Medicine, University of Leipzig, Liebigstr. 18, 04103 Leipzig, Germany,

33. INSERM UMR744, Institut Pasteur, Lille, France,

34. Centre for Information-based Medicine and School of Medicine and Public Health, University of Newcastle, Hunter Medical Research Institute, Newcastle, NSW, Australia,

35. Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’, CNR, Via P. Castellino 111, 80131 Napoli, Italy,

36. Department of Medical Genetics, University of Lausanne, Rue du Bugnon 27, CH, 1005 Lausanne, Switzerland,

37. Swiss Institute of Bioinformatics, Lausanne, Switzerland,

38. Department of Clinical Chemistry, Centre for Laboratory Medicine Tampere Finn, University of Tampere and Tampere University Hospital, Medi 2, 3th, floor, PO Box 2000, 33521 Tampere, Finland,

39. Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu, Riia 23, Tartu, Estonia,

40. Estonian Genome Center, University of Tartu (EGCUT), Tiigi 61b, Tartu, Estonia,

41. Clinical Research Centre, University of Dundee-Wellcome Trust Centre for Molecular Medicine, Level 7, Ninewells Hospital, Dundee DD1 9SY, Scotland,

42. Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’, Trieste, Italy,

43. Institute of Population Genetics, CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari, Italy,

44. Deparment of Cardiology, Leiden University Medical Center, Postzone C2-R, PO Box 9600, 2300 RC Leiden, The Netherlands,

45. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Socinstrasse 57, PO Box, Basel 4002, Switzerland,

46. University of Basel, Basel, Switzerland,

47. Division of Genetic Epidemiology, Innsbruck Medical University, Schoepfstraße 41, 6020 Innsbruck, Austria,

48. Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Via Olgettina 58, 20132 Milano, Italy,

49. Laboratory of Epidemiology, Demography, and Biometry, NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205, USA,

50. Human Genetics Center Houston, University of Texas Health Science Center, TX-1200 Herman Pressler Drive, Houston, TX 77030, USA,

51. Institute of Molecular Biology and Biochemistry and Department of Neurology, Medical University Graz, Harrachgasse 21 8010, Graz, Austria,

52. Division of Nephrology/Tufts Evidence Practice Center, Tufts University School of Medicine-Tufts Medical Center, Boston, MA 02111, USA,

53. Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA

54. Department of Internal Medicine and

55. Department of Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA

56. Abteilung Innere II, Universitätsklinikum Ulm, Albert-Einstein-Allee 23, Ulm 89081, Germany,

57. Helmholtz Zentrum München, German Research Center for Environmental Health, Institute of Epidemiology II, Neuherberg, Germany,

58. Center for Population Health Sciences, University of Edinburgh Medical School, UK-Teviot Place, Edinburgh EH8 9AG, Scotland,

59. Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia,

60. Croatian Centre for Global Health, Faculty of Medicine, University of Split, Soltanska 2, Split, Croatia,

61. Departments of Genetics and Developmental Biology, Stanford University, Stanford, CA 94305, USA

62. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine––Western General Hospital, Crewe Road, Edinburgh EH4 2XU, Scotland,

63. Institute of Clinical Molecular Biology, Christian-Albrechts University, Schittenhelmstr.12, Kiel 24105, Germany,

64. Section for Epidemiology, Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein, Niemannsweg 11, Kiel 24105, Germany,

65. Clinic for Prosthodontic Dentistry, Gerostomatology and Material Science, University of Greifswald, Rotgerberstr 8, Greifswald 17475, Germany,

66. Institute of Pharmacology, University of Greifswald, Friedrich-Loeffler-Str., 23d, Greifswald 17487, Germany,

67. Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz Arndt-University Greifswald, Ferdinand-Sauerbruch-Str., Greifswald 17475, Germany,

68. Clinic for Internal Medicine A, University of Greifswald, Friedrich-Loeffler-Str. 23a, Greifswald 17475, Germany,

69. Institute for Community Medicine, University of Greifswald, Walther-Rathenau-Str. 48, Greifswald 17487, Germany,

70. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK,

71. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK,

72. Department of Internal Medicine, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands,

73. INSERM U897, Université Victor Ségalen Bordeaux 2, ISPED case 11, 146 Rue Léo Saignat, F-33076 Bordeaux, France,

74. Centre for Vision Research, University of Sydney, Westmead Millennium Institute, Westmead Hospital, Sydney NSW 2145, Australia,

75. Centre for Eye Research Australia (CERA), University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia,

76. INSERM UMRS 1018-CESP Team 10, Univ Paris Sud, Villejuif, France,

77. Department of Clinical Physiology, University of Tampere and Tampere University Hospital, 33521-PO Box 2000, Tampere 33521, Finland,

78. Department of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku, PO Box 52, Turku 20521, Finland,

79. University of Trieste, Trieste, Italy,

80. Department of Medicine, University Medical Centre Mannheim, Theodor Kutzer Ufer 1-3, Mannheim 68167, Germany,

81. Robertson Centre for Biostatistics, University of Glasgow, Glasgow, Scotland,

82. Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland,

83. First Department of Internal Medicine, Paracelsus Medical University, Müllner Hauptstraße 48, Salzburg 5020, Austria,

84. Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 46, Lausanne 1011, CH, Switzerland,

85. University of Dundee-Biomedical Research Institute, Level 5, Ninewells Hospital Dundee DD1 9SY, Scotland,

86. Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands,

87. Interuniversity Cardiology Institute of the Netherlands (ICIN), Utrecht, The Netherlands,

88. Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands,

89. Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, MD, USA,

90. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, 2024 E Monument St., Suite 2-600, Baltimore, MD 21287, USA,

91. Department of Special Neurology, University Clinic of Neurology, Medical University Graz, Auenbruggerplatz 22, 8036 Graz, Austria,

92. Department of Epidemiology and School of Public Health, University of Medicine, 109 Observatory #4605, Ann Arbor, MI 48109-2029, USA,

93. Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA,

94. Institute of Physiology, University of Greifswald, Greifswald 17487, Germany,

95. Division of Nephrology, University of Maryland Medical School, Baltimore, MD, USA

96. University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Route de la Corniche 2, Epalinges 1066, CH, Switzerland and

97. Division of Endocrinology, Brigham and Women's Hospital, 75 Francis St., Boston, MA, USA

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference67 articles.

1. Prevalence of chronic kidney disease in population-based studies: systematic review;Zhang;BMC Public Health,2008

2. Prevalence of chronic kidney disease in the United States;Coresh;JAMA,2007

3. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification;National Kidney Foundation;Am. J. Kidney. Dis.,2002

4. Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean);Bochud;Kidney Int.,2005

5. Genomewide linkage analysis to serum creatinine, GFR, and creatinine clearance in a community-based population: the Framingham heart study;Fox;J. Am. Soc. Nephrol.,2004

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