Genome-wide meta-analysis of common variant differences between men and women

Author:

Boraska Vesna12,Jerončić Ana3,Colonna Vincenza14,Southam Lorraine1,Nyholt Dale R.5,William Rayner Nigel167,Perry John R.B.689,Toniolo Daniela10,Albrecht Eva11,Ang Wei12,Bandinelli Stefania13,Barbalic Maja14,Barroso Inês115,Beckmann Jacques S.1617,Biffar Reiner18,Boomsma Dorret19,Campbell Harry20,Corre Tanguy10,Erdmann Jeanette2122,Esko Tõnu232425,Fischer Krista23,Franceschini Nora26,Frayling Timothy M.8,Girotto Giorgia27,Gonzalez Juan R.2829,Harris Tamara B.30,Heath Andrew C.31,Heid Iris M.3233,Hoffmann Wolfgang34,Hofman Albert3536,Horikoshi Momoko67,Hua Zhao Jing37,Jackson Anne U.3839,Hottenga Jouke-Jan19,Jula Antti40,Kähönen Mika4142,Khaw Kay-Tee43,Kiemeney Lambertus A.44,Klopp Norman45,Kutalik Zoltán1646,Lagou Vasiliki67,Launer Lenore J.30,Lehtimäki Terho4742,Lemire Mathieu48,Lokki Marja-Liisa49,Loley Christina50,Luan Jian'an37,Mangino Massimo9,Mateo Leach Irene51,Medland Sarah E.5,Mihailov Evelin24,Montgomery Grant W.5,Navis Gerjan52,Newnham John12,Nieminen Markku S.53,Palotie Aarno1545556,Panoutsopoulou Kalliope1,Peters Annette57,Pirastu Nicola27,Polašek Ozren58,Rehnström Karola154,Ripatti Samuli54,Ritchie Graham R.S.159,Rivadeneira Fernando356036,Robino Antonietta27,Samani Nilesh J.61,Shin So-Youn1,Sinisalo Juha53,Smit Johannes H.62,Soranzo Nicole19,Stolk Lisette6036,Swinkels Dorine W.63,Tanaka Toshiko64,Teumer Alexander65,Tönjes Anke6667,Traglia Michela10,Tuomilehto Jaakko68697071,Valsesia Armand164672,van Gilst Wiek H.51,van Meurs Joyce B.J.6036,Smith Albert Vernon7374,Viikari Jorma6675,Vink Jacqueline M.19,Waeber Gerard76,Warrington Nicole M.12,Widen Elisabeth54,Willemsen Gonneke19,Wright Alan F.77,Zanke Brent W.78,Zgaga Lina2079,Boehnke Michael3839,d'Adamo Adamo Pio27,de Geus Eco19,Demerath Ellen W.80,den Heijer Martin8182,Eriksson Johan G.8384858687,Ferrucci Luigi88,Gieger Christian11,Gudnason Vilmundur7374,Hayward Caroline77,Hengstenberg Christian89,Hudson Thomas J.4890,Järvelin Marjo-Riitta91929394,Kogevinas Manolis28299596,Loos Ruth J.F.37,Martin Nicholas G.5,Metspalu Andres232425,Pennell Craig E.12,Penninx Brenda W.979899,Perola Markus54100,Raitakari Olli101102,Salomaa Veikko83,Schreiber Stefan103,Schunkert Heribert2122,Spector Tim D.9,Stumvoll Michael6667,Uitterlinden André G.356036,Ulivi Sheila104,van der Harst Pim51,Vollenweider Peter76,Völzke Henry34,Wareham Nicholas J.37,Wichmann H.-Erich33105106,Wilson James F.20,Rudan Igor220,Xue Yali1,Zeggini Eleftheria1,

Affiliation:

1. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK,

2. Department of Medical Biology,

3. Department for Research in Biomedicine and Health and

4. Institute of Genetics and Biophysics ‘A. Buzzati-Traverso’, National Research Council (CNR), Naples, Italy,

5. Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia,

6. Wellcome Trust Centre for Human Genetics and

7. Oxford Centre for Diabetes, Endocrinology, and Metabolism, University of Oxford, Oxford, UK,

8. Genetics of Complex Traits, Peninsula Medical School, University of Exeter, UK,

9. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK,

10. Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy,

11. Institute of Genetic Epidemiology, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany,

12. School of Women's and Infants’ Health, The University of Western Australia, Perth, Western Australia, Australia,

13. Geriatric Unit, Azienda Sanitaria di Firenze, Florence, Italy,

14. Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA,

15. University of Cambridge Metabolic Research Labs and

16. Department of Medical Genetics, University of Lausanne, Switzerland,

17. Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland,

18. Department of Prosthetic Dentistry, Gerostomatology and Dental Materials and

19. Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands,

20. Centre for Population Health Sciences, University of Edinburgh, Scotland, UK,

21. Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany,

22. Deutsches Zentrum für Herz-Kreislauf-Forschung e. V. (DZHK) and

23. Estonian Genome Center and

24. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia,

25. Estonian Biocenter, Tartu, Estonia,

26. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA,

27. Institute for Maternal and Child Health - IRCCS ‘Burlo Garofolo’ – Trieste, University of Trieste, Italy,

28. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain,

29. CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain,

30. Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA,

31. Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA,

32. Public Health and Gender Studies, Institute of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany,

33. Institute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany,

34. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany,

35. Department of Epidemiology and

36. Netherlands Consortium of Healthy Ageing, Rotterdam, The Netherlands,

37. MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK,

38. Department of Biostatistics and

39. Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA,

40. National Institute for Health and Welfare, Department of Chronic Disease Prevention, Population Studies Unit, Turku, Finland,

41. Department of Clinical Physiology and

42. Tampere University Hospital, Tampere, Finland,

43. Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK,

44. Department of Epidemiology, Biostatistics and HTA & Department of Urology,

45. Unit for Molecular Epidemiology and

46. Swiss Institute of Bioinformatics, Lausanne, Switzerland,

47. Department of Clinical Chemistry, Fimlab Laboratories, University of Tampere, Tampere, Finland,

48. Ontario Institute for Cancer Research, Toronto, Canada,

49. Transplantation Laboratory, Haartman Institute and

50. Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Lübeck, Germany,

51. Department of Cardiology,

52. Department of Internal Medicine and

53. Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland,

54. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland,

55. Department of Medical Genetics, University and University Central Hospital of Helsinki, Helsinki, Finland,

56. The Broad Institute of MIT and Harvard, Cambridge, USA,

57. Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany,

58. Department of Public Health, University of Split School of Medicine, Split, Croatia,

59. European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK,

60. Department of Internal Medicine, Erasmus MC Rotterdam, The Netherlands,

61. Department of Cardiovascular Sciences, University of Leicester, Leicester, UK,

62. Department of Psychiatry, EMGO Institute, Center for Neurogenomic and Cognitive Research and

63. Department of Laboratory Medicine,

64. Clinical Research Branch, National Institute of Aging, National Institute on Aging, Baltimore MD 21250, USA,

65. Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany,

66. Department of Medicine and

67. IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany,

68. Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki 00271, Finland,

69. South Ostrobothnia Central Hospital, Seinäjoki 60220, Finland,

70. Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid 28046, Spain,

71. Centre for Vascular Prevention, Danube-University Krems, Krems 3500, Austria,

72. Ludwig Institute for Cancer Research, Lausanne, Switzerland,

73. Icelandic Heart Association, Kopavogur, Iceland,

74. University of Iceland, Reykjavik, Iceland,

75. Turku University Hospital, Turku, Finland,

76. Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland,

77. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK,

78. Ottawa Hospital Research Institute, Ottawa, Canada,

79. Andrija Stampar School of Public Health, School of Medicine, University of Zagreb, Croatia,

80. Division of Epidemiology & Community Health, University of Minnesota, MN, USA,

81. Department of Endocrinology and

82. Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands,

83. Department of Chronic Disease Prevention, Chronic Disease Epidemiology and Prevention Unit and

84. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland,

85. University Central Hospital, Unit of General Practice, Helsinki, Finland,

86. Folkhalsan Research Centre, Helsinki, Finland,

87. Vasa Central Hospital, Vasa, Finland,

88. Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA,

89. Klinik und Poliklinik für Innere Medizin II, Regensburg, Germany,

90. Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, Canada,

91. Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK,

92. Institute of Health Sciences and

93. Biocenter Oulu, University of Oulu, Oulu, Finland,

94. National Institute for Health and Welfare, Oulu, Finland,

95. IMIM (Hospital del Mar Research Institute), Barcelona, Spain,

96. National School of Public Health, Athens, Greece,

97. Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands,

98. Department of Psychiatry, EMGO Institute, Institute for Neurosciences, VU University Medical Centre, Amsterdam, The Netherlands,

99. Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands,

100. Department of Chronic Disease Prevention, Unit of Public Health Genomics, National Institute for Health and Welfare, Helsinki, Finland,

101. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland,

102. The Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland,

103. Institut für Klinische Molekularbiologie, Christian-Albrechts Universität, Kiel, Germany,

104. Institute for Maternal and Child Health - IRCCS ‘Burlo Garofolo’, Trieste, Italy,

105. Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany,

106. Klinikum Grosshadern, Munich, Germany

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Reference32 articles.

1. Declining sex ratio in a first nation community;Mackenzie;Environ. Health Perspect.,2005

2. Sex ratio at birth and racial differences: why do black women give birth to more females than non-black women?;Kaba;Afr. J. Reprod. Health,2008

3. The human sex ratio. Part 1: a review of the literature;James;Hum. Biol.,1987

4. Determinants of the sex ratio at birth: review of recent literature;Chahnazarian;Soc. Biol.,1988

5. A two-generation study of human sex-ratio variation;Curtsinger;Am. J. Hum. Genet.,1983

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