Effectiveness and tolerability of dolutegravir/lamivudine for the treatment of HIV-1 infection in clinical practice
Author:
Suárez-García Inés123ORCID, Alejos Belén4, Hernando Victoria25, Viñuela Laura67, Vera García Mar8, Rial-Crestelo David29ORCID, Pérez Elías María Jesús210ORCID, Albendín Iglesias Helena1112, Peraire Joaquim21314, Tiraboschi Juan15ORCID, Díaz Asunción25, Moreno Santiago210ORCID, Jarrín Inma216, Moreno Santiago, Jarrín Inma, Dalmau David, Navarro M Luisa, González M Isabel, Garcia Federico, Poveda Eva, Iribarren Jose Antonio, Gutiérrez Félix, Rubio Rafael, Vidal Francesc, Berenguer Juan, González Juan, Muñoz-Fernández M Ángeles, Jarrín Inmaculada, Moreno Cristina, Rava Marta, Izquierdo Rebeca, del Romero Raposo Jorge, Marco Cristina, Puente Julián, Muñoz-Fernández M Ángeles, Mauleón Elba, Juárez Roxana, Portilla Joaquín, Portilla Irene, Merino Esperanza, García Gema, Agea Iván, Sánchez-Payá José, Rodríguez Juan Carlos, Giner Livia, Reus Sergio, Boix Vicente, Torrus Diego, Pérez Verónica, Portilla Julia, Alemán María Remedios, Hernández Jehovana, Lirola Ana López, García Dácil, Díaz-Flores Felicitas, Alonso M Mar, Pelazas Ricardo, Asensi Víctor, Rivas M Eugenia, Suarez-Zarracina Tomás, Valle-Garay Eulalia, Díaz Javier, Pulido Federico, Rubio Rafael, Bisbal Otilia, Hernando M Asunción, Rial David, de Lagarde María, Arce Octavio, Pinto Adriana, Bermejo Laura, Santacreu Mireia, Navarro Roser, Gonzalez Candela, Iribarren Jose Antonio, Aramburu M José, Camino Xabier, von Wichmann Miguel Ángel, Goenaga Miguel Ángel, Bustinduy M Jesús, Azkune Harkaitz, Ibarguren Maialen, Kortajarena Xabier, Álvarez-Rodriguez Ignacio, Gil Leire, Martínez Lourdes, Gutiérrez Félix, Masiá Mar, Robledano Catalina, Padilla Sergio, Abellán Javier Garcia, Mascarell Paula, Adsuar Araceli, Pascual Rafael, Carvajal Mar, Fernández Marta, García José Alberto, Botella Ángela, de la Rica Alba, Ding Carolina, García-Sánchez Lidia, Ena Nuria, Barber Xavier, Agullo Vanessa, Pascual Reyes, Telenti Guillermo, Guillén Lucia, López Leandro, Vallejo Jennifer, Gonzalo-Jimenez Nieves, Ruiz Montserrat, Galiana Antonio, Muga Roberto, Sanvisens Arantza, Fuster Daniel, de Quirós Juan Carlos López Bernaldo, Gutierrez Isabel, Ramírez Margarita, Padilla Belén, Gijón Paloma, Aldamiz-Echevarría Teresa, Tejerina Francisco, Diez Cristina, Pérez Leire, Fanciulli Chiara, Corral Saray, Peraire Joaquín, Martí Anna, Viladés Consuelo, Vargas Montserrat, Olona Montserrat, Rull Anna, Alba Verónica, Yeregui Elena, Masip Jenifer, García-Pardo Graciano, Bertomeu Frederic Gómez, Espineira Sonia, Montero Marta, Blanes Marino, Tasias María, Calabuig Eva, Salavert Miguel, Fernández Juan, Segarra Inmaculada, González-García Juan, Delgado-Hierro Ana, Arribas José Ramón, Arribas Victor, Bernardino Jose Ignacio, Busca Carmen, Cano Joanna, Cadiñanos Julen, Castro Juan Miguel, Escosa Luis, Falces Iker, Herranz Pedro, Hontañón Victor, García Milagros, González-Baeza Alicia, Martín-Carbonero M Luz, Mayoral Mario, Mellado Mª Jose, Micán Rafael, de Miguel Rosa, Montejano Rocío, Montes M Luisa, Moreno Victoria, Rodés Luis Ramos Berta, Sainz Talía, Sendagorta Elena, Valencia Eulalia, Blanco Jose Ramón, Pérez-Martínez Laura, Oteo José Antonio, Ibarra Valvanera, Metola Luis, Sanz Mercedes, Martínez Rosa, Sampériz Gloria, Dalmau David, Martinez Marina, Jaén Angels, Cairó Mireia, Martinez-Lacasa Javier, Font Roser, Gisbert Laura, Rivero María, Piérola Beatriz, Goikoetxea Maider, Gracia María, Ibero Carlos, Moreno Estela, Repáraz Jesús, Navarro Gemma, Garcia Manel Cervantes, Isbert Sonia Calzado, Vilasaro Marta Navarro, Garcia Belen Lopez, de los Santos Ignacio, de los Santos Alejandro, Sanz Jesús, García-Fraile Lucio, Martín Enrique, Sánchez-Cerrillo Ildefonso, Calvet Marta, Barrios Ana, Bautista Azucena, Sáez Carmen, Ciudad Marianela, Gutiérrez Ángela, Moreno Santiago, del Campo Santos, Casado José Luis, Dronda Fernando, Moreno Ana, Pérez M Jesús, Serrano Sergio, Vivancos M Jesús, Martínez-Sanz Javier, Vallejo Alejandro, Sanchez Matilde, Pérez-Molina Jose Antonio, Hermida José Manuel, Bernal Enrique, Alcaraz Antonia, Bravo Joaquín, Muñoz Ángeles, Tomás Cristina, Martínez Mónica, Villalba M Carmen, García Federico, Martínez Clara, Hernández José, Medina Leopoldo Muñoz, Álvarez Marta, Chueca Natalia, Vinuesa David, de Salazar Adolfo, Fuentes Ana, Guirao Emilio, Viñuela Laura, Ruiz-Sancho Andrés, Anguita Francisco, Del Romero Jorge, Raposo Montserrat, Rodríguez Carmen, Puerta Teresa, Carrió Juan Carlos, Vera Mar, Ballesteros Juan, Ayerdi Oskar, Baza Begoña, Orviz Eva, Antela Antonio, Losada Elena, Riera Melchor, Peñaranda María, Ribas M Angels, Campins Antoni A, Garcia-Gazalla Mercedes, Fanjul Francisco J, Murillas Javier, Homar Francisco, Vilchez Helem H, Martin Luisa, Payeras Antoni, Santos Jesús, López María, Gómez Cristina, Viciana Isabel, Palacios Rosario, López-Cortés Luis Fernando, Espinosa Nuria, Roca Cristina, Llaves Silvia, Tiraboschi Juan Manuel, Imaz Arkaitz, Silva Ana Karina, Saumoy María, Scévola Sofía Catalina, Curran Adrián, Falcó Vicenç, Navarro Jordi, Burgos Joaquin, Suanzes Paula, García Jorge, Descalzo Vicente, Álvarez Patricia, Planas Bibiana, Sanchiz Marta, Rodríguez Lucía, Olalla Julián, Sánchez M José, Pérez Javier, del Arco Alfonso, de la Torre Javier, Prada José Luis, Martínez Onofre Juan, Martinez Lorena, Vera Francisco Jesús, García Josefina, Alcaraz Begoña, Guirao Antonio Jesús Sánchez, Mena Álvaro, Castro Ángeles, Pernas Berta, Vázquez Pilar, López Soledad, Ibarra Sofía, García Guillermo, Mirena Josu, Ferrero Oscar Luis, López Josefina, Cámara M Mar, de la Peña Mireia, Lopez Miriam, Lopez Iñigo, Lombide Itxaso, Polo Victor, de Miguel Joana, Galera Carlos, Fernández Marian, Albendin Helena, Castillo Antonia, Iborra Asunción, Moreno Antonio, Merlos M Angustias, Vidal Asunción, Amador Concha, Pasquau Francisco, Gil Concepción, Algado Jose Tomás, Suarez-García Inés, Malmierca Eduardo, González-Ruano Patricia, Ruiz M Pilar, Pascual José Francisco, Balsalobre Luz, Somodevilla Ángela, López M Villa, Omar Mohamed, Herrero Carmen, Gómez M Amparo, de Zarraga Miguel Alberto, Pérez Desiré, Estrada Vicente, Sanz Nieves, Cabello Noemí, Vergas Jorge, Núñez M Jose, Sagastagoitia Iñigo, Homen Reynaldo, Muñoz Ana, Górgolas Miguel, Cabello Alfonso, Álvarez Beatriz, Prieto Laura, Carrillo Irene, Al-Hayani Aws, Sanz José, Arranz Alberto, Hernández Cristina, Novella María, Galindo M José, Ferrer Ana, Román Antonio Rivero, Ruíz Inma, Juárez Antonio Rivero, López Pedro, Machuca Isabel, Frías Mario, Camacho Ángela, Pérez Ignacio, Corona Diana, Pérez Ignacio, Corona Diana, Cervero Miguel, Torres Rafael, Sánchez Juan Macías, Rincón Pilar, Real Luis Miguel, Corma Anais, Fernández Marta, González-Serna Alejandro, Poveda Eva, Pérez Alexandre, Morano Luis, Miralles Celia, Ocampo Antonio, Pousada Guillermo, Patiño Lucía, Dueñas Carlos, Gutiérrez Sara, Tapia Elena, Novoa Cristina, Egües Xjoylin, Telleria Pablo,
Affiliation:
1. Infectious Diseases Group, Department of Internal Medicine, Hospital Universitario Infanta Sofía, FIIB HUIS HHEN , Madrid , Spain 2. CIBER de Enfermedades Infecciosas (CIBERINFEC) , Madrid , Spain 3. Department of Medicine, Universidad Europea , Madrid , Spain 4. Independent Researcher , Madrid , Spain 5. HIV, STI and Hepatitis Surveillance Unit, National Center of Epidemiology, Institute of Health Carlos III , Madrid , Spain 6. Department of Microbiology, Hospital Universitario Clínico San Cecilio , Granada , Spain 7. Instituto de Investigación Biosanitaria Granada , Granada , Spain 8. Centro Sanitario Sandoval, IdISSC, Hospital Clínico San Carlos , Madrid , Spain 9. David Rial-Crestelo, HIV Unit, Hospital Universitario 12 de Octubre-Imas12 , Madrid , Spain 10. Department of Infectious Diseases, Hospital Universitario Ramón y Cajal, IRYCIS , Madrid , Spain 11. HIV and STI Unit, Department of Internal Medicine, Hospital Universitario Virgen de la Arrixaca , Murcia , Spain 12. Instituto Murciano de Investigación Biosanitaria (IMIB) , Murcia , Spain 13. Hospital Universitari de Tarragona Joan XXIII, IISPV , Tarragona , Spain 14. Universitat Rovira i Virgili , Tarragona , Spain 15. HIV Unit, Department of Infectious Diseases, Hospital Universitari de Bellvitge, Hospitalet de Llobregat , Barcelona , Spain 16. National Centre of Epidemiology, Institute of Health Carlos III , Madrid , Spain
Abstract
Abstract
Objectives
To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) during the years 2018–2021.
Methods
We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL) <50 copies/mL] and the change in CD4 cell counts at 24 and 48 (±12) weeks after initiation with dolutegravir/lamivudine or other first-line ART regimens.
Results
We included 2160 treatment-naive subjects, among whom 401 (18.6%) started with dolutegravir/lamivudine. The remaining subjects started bictegravir (BIC)/emtricitabine (FTC)/tenofovir alafenamide (TAF) (n = 949, 43.9%), DTG + FTC/tenofovir disoproxil fumarate (TDF) (n = 282, 13.1%), DTG/3TC/abacavir (ABC) (n = 255, 11.8%), darunavir (DRV)/cobicistat(COBI)/FTC/TAF (n = 147, 6.8%) and elvitegravir (EVG)/COBI/FTC/TAF (n = 126, 5.8%). At 24 and 48 weeks after starting dolutegravir/lamivudine, 91.4% and 93.8% of the subjects, respectively, achieved VS. The probability of achieving VS with dolutegravir/lamivudine was not significantly different compared with any other regimen at 24 or 48 weeks, with the exception of a lower chance of achieving VS at 24 weeks for DRV/COBI/FTC/TAF (adjusted OR: 0.47; 95% CI: 0.30–0.74) compared with dolutegravir/lamivudine.
For the analysis of treatment-experienced virally suppressed subjects we included 1456 individuals who switched to dolutegravir/lamivudine, among whom 97.4% and 95.5% maintained VS at 24 and 48 weeks, respectively. During the first 48 weeks after dolutegravir/lamivudine initiation, 1.0% of treatment-naive and 1.5% of treatment-experienced subjects discontinued dolutegravir/lamivudine due to an adverse event.
Conclusions
In this large multicentre cohort, effectiveness and tolerability of dolutegravir/lamivudine were high among treatment-naive and treatment-experienced subjects.
Funder
Instituto de Salud Carlos III Red Temática de Investigación Cooperativa en Sida ISCIII-Subdirección General de Evaluación Fondo Europeo de Desarrollo Regional ViiV Healthcare
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)
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