Power of neutrality tests for detecting natural selection

Author:

Tanaka Tomotaka1,Hayakawa Toshiyuki12,Teshima Kosuke M3ORCID

Affiliation:

1. Graduate School of System Life Science, Kyushu University , Fukuoka 819-0395 , Japan

2. Faculty of Arts and Science, Kyushu University , Fukuoka 819-0395 , Japan

3. Department of Biology, Faculty of Science, Kyushu University , Fukuoka 819-0395 , Japan

Abstract

Abstract Detection of natural selection is one of the main interests in population genetics. Thus, many tests have been developed for detecting natural selection using genomic data. Although it is recognized that the utility of tests depends on several evolutionary factors, such as the timing of selection, strength of selection, frequency of selected alleles, demographic events, and initial frequency of selected allele when selection started acting (softness of selection), the relationships between such evolutionary factors and the power of tests are not yet entirely clear. In this study, we investigated the power of 4 tests: Tajiama's D, Fay and Wu's H, relative extended haplotype homozygosity (rEHH), and integrated haplotype score (iHS), under ranges of evolutionary parameters and demographic models to quantitatively expand the understanding of approaches for detecting selection. The results show that each test detects selection within a limited parameter range, and there are still wide ranges of parameters for which none of these tests work effectively. In addition, the parameter space in which each test shows the highest power overlaps the empirical results of previous research. These results indicate that our present perspective of adaptation is limited to only a part of actual adaptation.

Funder

JSPS KAKENHI

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Divergence time shapes gene reuse during repeated adaptation;Trends in Ecology & Evolution;2023-12

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