Retreatment With Sofosbuvir Plus Grazoprevir/Elbasvir Plus Ribavirin of Patients With Hepatitis C Virus Genotype 1 or 4 Who Previously Failed an NS5A- or NS3-Containing Regimen: The ANRS HC34 REVENGE Study

Author:

de Lédinghen Victor12,Laforest Claire3,Hézode Christophe4,Pol Stanislas5,Renault Alain36,Alric Laurent7,Larrey Dominique8,Métivier Sophie9,Tran Albert10,Jézéquel Caroline11,Samuel Didier12,Zoulim Fabien13,Tual Christelle3,Pailhé Aurélie14,Gibowski Séverine14,Bourlière Marc15,Bellissant Eric36,Pawlotsky Jean-Michel16

Affiliation:

1. Hepatology Unit, University Hospital, CHU Bordeaux, Pessac

2. INSERM, Université Bordeaux, UMR1053 Bordeaux Research in Translational Oncology, BaRITOn

3. CHU Rennes, Service Pharmacologie, and INSERM, CIC 1414

4. Service d’Hépatologie, CHU Henri-Mondor, AP-HP, Université Paris-Est, INSERM U955, Créteil

5. Université Paris Descartes, Hepatology Department, Cochin Hospital, APHP, INSERM U1223, UMS-20 and Center for Translational Science, Institut Pasteur

6. Université Rennes 1, Faculté de médecine, laboratoire de pharmacologie

7. Department of Internal Medicine and Digestive Diseases, CHU Purpan, UMR 152, IRD Toulouse 3 University

8. Hepatology Unit and INSERM 1183, CHU Montpellier

9. Hepatology Unit, CHU Purpan, Toulouse

10. Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, “Hepatic Complications in Obesity,” and University Hospital of Nice, Digestive Centre, Cedex

11. Hepatology Unit, CHU Rennes

12. Hepatology Unit, APHP Paul Brousse, Villejuif

13. Hepatology Unit, Hospices Civils de Lyon, and INSERM U1052, Paris

14. France Recherche Nord & Sud Sida-HIV Hépatites, Paris

15. Hepatology Unit, Hôpital Saint Joseph, Marseille

16. National Reference Center for Viral Hepatitis B, C, and D, Department of Virology, Hôpital Henri Mondor, Université Paris-Est, and INSERM U955, Créteil, France

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference14 articles.

1. Hepatitis C virus resistance to direct-acting antiviral drugs in interferon-free regimens;Pawlotsky;Gastroenterology,2016

2. NS5A resistance-associated substitutions in patients with genotype 1 hepatitis C virus: prevalence and effect on treatment outcome;Zeuzem;J Hepatol,2017

3. EASL recommendations on treatment of hepatitis C 2016;European Association for the Study of the Liver;J Hepatol,2017

4. C-SWIFT retreatment (part B): 12 weeks of elbasvir/grazoprevir with sofosbuvir and ribavirin successfully treated GT1-infected subjects who failed short-duration all-oral therapy;Lawitz;Hepatology,2015

5. Simeprevir (SMV) plus daclatasvir (DCV) and sofosbuvir (SOF) in treatment-naive and -experienced patients with chronic hepatitis C virus genotype 1 or 4 infection and decompensated liver disease: interim results from the phase II IMPACT study;Lawitz;J Hepatol,2015

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