This chapter argues that, as an analytic proposition and industrial policy challenge, it is realistic that global CO2 emissions can be driven to net zero by 2050, the goal set in 2018 by the IPCC. This will require an average level of investment spending of about 2.5 per cent of global GDP per year, focused in two areas: (1) dramatically improving energy-efficiency standards in the stock of buildings, automobiles and public transportation systems, and industrial production processes; and (2) equally dramatically expanding the supply of clean renewable energy sources—primarily solar and wind power—available at competitive prices to all sectors and in all regions of the globe. The chapter examines the industrial and financial policy measures that will be needed to support this global clean energy investment project, focusing on approaches that have been implemented throughout the world to varying degrees.