Making music require musicians to show optimal levels of physical, cognitive, emotional, and technical skills, which at times can be detrimental to their health and wellbeing. The many job challenges that musicians face related to work culture and practices, job insecurity, antisocial work patterns, and other psychosocial and financial challenges can also exacerbate the risks for musicians’ health and wellbeing. Therefore, promoting healthy lifestyles play a central role in helping musicians achieve the adequate physical and mental conditions to meet the demands of making music, preventing ill health and optimizing their performance. This chapter is divided into two sections. The first section introduces approaches to health promotion and specific behavioral change models, offering an overview of relevant considerations in health prevention, promotion, and education that explain how people adopt healthier lifestyles. We also discuss the concept of health literacy as an asset in music settings that can empower musicians to adopt healthy lifestyles. The second section focuses on practical applications, in particular psychosocial protective factors, healthy practice and performance, and additional strategies to sustain healthy lifestyles. We believe that healthy lifestyles not only protect musicians’ health but have added value to unleash musicians’ true potential and sustain performance excellence.