The Oxford Handbook of the Positive Humanities is the foundational scientific reference for the new and rapidly growing field of the Positive Humanities, an emerging interdisciplinary domain of inquiry and practice focused on the arts and humanities in relation to human flourishing. This Handbook comprises 38 chapters authored by nearly 70 leading experts across a wide range of academic disciplines. The volume begins with an overview of the science and culture of human flourishing, covering historical and current trends in this literature. Next, contributors consider the well-being benefits of engagement with the arts and humanities, identifying neurological, cognitive, emotional, behavioral, and social pathways to human flourishing. These pathways lead to detailed investigations of individual fields within the arts and humanities, including music, art, theatre, film, literature, philosophy, history, and religion. Along the way, the book synthesizes theory, research, and exemplary practice, concluding with thought-provoking discussions of avenues for public engagement and policy. With its expansive coverage of both the field as a whole and specialized disciplinary and interdisciplinary drivers, this Handbook advances the literature on the theory and science of well-being and extends the scope of the arts and humanities.