This chapter provides an overview of business and management in Southeast Asia. Drawing on the business systems (varieties of capitalism) literature, it lays out the institutional features of business in the region: Singapore as an exponent of advanced city economies and the remainder of the region as emerging Southeast Asian markets. The chapter identifies key historical themes and material forces that have led to the emergence of these ways of organizing economies in the region and discusses their key characteristics. The chapter further discusses typical strategies by foreign direct investors coming into the region as well as the state of multinational enterprises emerging from the region.