Against the background of policy debates by advocates and opponents like nongovernmental organizations about regulation of biotechnology, this chapter summarizes communication by mass media about biotechnology and genetically modified organisms (GMOs) in the public sphere. On the one hand there are several Eurobarometer surveys dealing with knowledge, perceptions, and opinions for or against biotechnology in the different European countries, and on the other hand, several analyses of media content have been realized, focusing on key events like the sheep Dolly and issues, cycles, or media frames like scientific progress, economic prospects, ethics, or Pandora’s box and arguments for or against biotechnology. The existing research demonstrates how media and lay persons perceive and construct risks as well benefits of new technologies like biotechnology and GMOs.