This chapter details how AI affects, and will continue to affect, the Global South. The term “South” has a history connected with the “Third World” and has referred to countries that share postcolonial history and certain development goals. However, scholars have expanded and refined on it to include different kinds of marginal, disenfranchised populations such that the South is now a plural concept—there are Souths. The AI-related risks for Southern populations include concerns of discrimination, bias, oppression, exclusion, and bad design. These can be exacerbated in the context of vulnerable populations, especially those without access to human rights law or institutional remedies. The chapter then outlines these risks as well as the international human rights law that is applicable. It argues that a human rights–centric, inclusive, empowering context-driven approach is necessary.