Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection-Reference-Cited by-同舟云学术

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Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection

Published:2017-05-05 Issue:15 Volume:26 Page:2912-2922
ISSN:0964-6906
Container-title:Human Molecular Genetics
language:en
Short-container-title:

Author:

Grandhi Sneha¹,Bosworth Colleen¹,Maddox Wesley¹,Sensiba Cole¹,Akhavanfard Sara¹²,Ni Ying¹²,LaFramboise Thomas¹²³

Affiliation:

1. Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA

2. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA

3. Center for Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA

Funder

American Cancer Society

National Cancer Institute

National Institute of General Medical Sciences

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Link

http://academic.oup.com/hmg/article-pdf/26/15/2912/24340080/ddx172.pdf

Reference58 articles.

1. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis;Ishikawa;Science,2008

2. Topology of superoxide production from different sites in the mitochondrial electron transport chain;St-Pierre;J. Biol. Chem,2002

3. The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants;Mattiazzi;Hum. Mol. Genet,2004

4. Mitochondrial DNA mutations in human disease;Taylor;Nat. Rev. Genet,2005

5. The maintenance of mitochondrial DNA integrity–critical analysis and update;Alexeyev;Cold Spring Harb. Perspect. Biol,2013

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