The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta

Author:

Gioia Roberta1,Tonelli Francesca1,Ceppi Ilaria1,Biggiogera Marco2,Leikin Sergey3,Fisher Shannon4,Tenedini Elena5,Yorgan Timur A.6,Schinke Thorsten6,Tian Kun7,Schwartz Jean-Marc7,Forte Fabiana8,Wagener Raimund8,Villani Simona9,Rossi Antonio1,Forlino Antonella1

Affiliation:

1. Department of Molecular Medicine, Biochemistry Unit, University of Pavia, Pavia, Italy,

2. Department of Biology and Biotechnology, University of Pavia, Pavia, Italy

3. Section on Physical Biochemistry, Eunice Kennedy Shriver NICHD, NIH, Bethesda, MD, USA

4. Department of Pharmacology & Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA

5. Center for Genome Research, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy

6. Institute of Osteology and Biomechanic, Center for Experimental Medicine, University of Hamburg, Hamburg, Germany

7. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK

8. Medical Faculty, Center for Biochemistry, Center for Molecular Medicine, University of Cologne, Cologne, Germany

9. Department of Public Health and Experimental and Forensic Medicine, Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, Italy

Funder

Fondazione Cariplo

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

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