Unexpected false-negative result in a traveller’s malaria diagnosis-Reference-Cited by-同舟云学术

Unexpected false-negative result in a traveller’s malaria diagnosis

Published:2022-10-27 Issue:1 Volume:30 Page:
ISSN:1195-1982
Container-title:Journal of Travel Medicine
language:en
Short-container-title:

Author:

Perez-Ugarte Arantxa¹,Rubio Maturana Carles²³^ORCID,Silgado Aroa¹⁴⁵,Zarzuela Serrat Francesc¹,Goterris Lidia¹,Paredes-Carmona Fernando⁶,Sulleiro Elena¹⁴⁵

Affiliation:

1. Microbiology Department, Vall d’Hebron University Hospital, PROSICS Barcelona, Universitat Autònoma de Barcelona , Barcelona 08035 , España

2. Microbiology Department , Vall d’Hebron Research Institute (VHIR), , Barcelona 08035 , España

3. Universitat Autònoma de Barcelona , Vall d’Hebron Research Institute (VHIR), , Barcelona 08035 , España

4. CIBERINFEC , ISCIII- CIBER Infectious Diseases, , Madrid , Spain

5. Instituto de Salud Carlos III , ISCIII- CIBER Infectious Diseases, , Madrid , Spain

6. Department of Paediatrics, Arnau de Vilanova University Hospital , Lleida 25198 , Spain

Abstract

A 4-year-old traveller returned from Senegal with symptoms compatible with malaria. Plasmodium falciparum HRP-2 antigen detection was negative, whereas panmalarial aldolase was positive. Microscopy confirmed the presence of P. falciparum trophozoites with parasitaemia of 16%. Discarding other causes of false-negative antigen detection, this is a rare case of prozone effect.

Publisher

Oxford University Press (OUP)

Subject

General Medicine

Link

https://academic.oup.com/jtm/advance-article-pdf/doi/10.1093/jtm/taac124/47191178/taac124.pdf

Reference5 articles.

1. A multiplex qPCR approach for detection of pfhrp2 and pfhrp3 gene deletions in multiple strain infections of Plasmodium falciparum;Schindler;Nat Res Sci Rep,2019

2. Assessment of the prozone effect in malaria rapid diagnostic tests;Gillet;Malar J,2009

3. Failure of rapid diagnostic tests in Plasmodium falciparum malaria cases among travelers to the UK and Ireland: identification and characterisation of the parasites;Nolder;Int J Infect Dis,2021

4. Prozone in malaria rapid diagnostics tests: how many cases are missed?;Gillet;Malar J,2011

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Usefulness of serial testing for the diagnosis of malaria in cases of fever upon return from travel;Journal of Travel Medicine;2024-03-03