Global disparities in the treatment of idiopathic inflammatory myopathies: results from an international online survey study-Reference-Cited by-同舟云学术

Global disparities in the treatment of idiopathic inflammatory myopathies: results from an international online survey study

Published:2023-05-25 Issue: Volume: Page:
ISSN:1462-0324
Container-title:Rheumatology
language:en
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Author:

Ziade Nelly¹²^ORCID,Aoude Marc¹²^ORCID,Hmamouchi Ihsane³⁴^ORCID,R. Naveen⁵^ORCID,Lilleker James B⁶⁷^ORCID,Sen Parikshit⁸^ORCID,Joshi Mrudula⁹^ORCID,Agarwal Vishwesh¹⁰^ORCID,Kardes Sinan¹¹^ORCID,Day Jessica¹²¹³¹⁴^ORCID,Makol Ashima¹⁵^ORCID,Milchert Marcin¹⁶^ORCID,Gheita Tamer¹⁷^ORCID,Salim Babur¹⁸^ORCID,Velikova Tsvetelina¹⁹^ORCID,Edgar Gracia-Ramos Abraham²⁰^ORCID,Parodis Ioannis²¹²²^ORCID,Nikiphorou Elena²³²⁴^ORCID,Chatterjee Tulika²⁵^ORCID,Tan Ai Lyn²⁶²⁷^ORCID,Saavedra Miguel A²⁸^ORCID,Shinjo Samuel Katsuyuki²⁹^ORCID,Knitza Johannes³⁰^ORCID,Kuwana Masataka³¹^ORCID,Nune Arvind³²^ORCID,Cavagna Lorenzo³³³⁴^ORCID,Distler Oliver³⁵^ORCID,Chinoy Hector⁵³⁶³⁷^ORCID,Agarwal Vikas⁴^ORCID,Aggarwal Rohit³⁸^ORCID,Gupta Latika⁶³⁹⁴⁰^ORCID,Barman Bhupen,Singh Yogesh Preet,Ranjan Rajiv,Jain Avinash,Pandya Sapan C,Pilania Rakesh Kumar,Sharma Aman,Manesh Manoj M,Gupta Vikas,Kavadichanda Chengappa G,Patro Pradeepta Sekhar,Ajmani Sajal,Phatak Sanat,Goswami Rudra Prosad,Chowdhury Abhra Chandra,Mathew Ashish Jacob,Shenoy Padnamabha,Asranna Ajay,Bommakanti Keerthi Talari,Shukla Anuj,Pandey Arun Kumar R,Chandwar Kunal,Cansu Döndü Üsküdar,Pauling John D,Wincup Chris,Del Papa Nicoletta,Sambataro Gianluca,Fabiola Atzeni,Govoni Marcello,Parisi Simone,Bocci Elena Bartoloni,Sebastiani Gian Domenico,Fusaro Enrico,Sebastiani Marco,Quartuccio Luca,Franceschini Franco,Sainaghi Pier Paolo,Orsolini Giovanni,De Angelis Rossella,Danielli Maria Giovanna,Venerito Vincenzo,Traboco Lisa S,Wibowo Suryo Anggoro Kusumo,Tehozol Erick Adrian Zamora,Serrano Jorge Rojas,García-De La Torre Ignacio,Loarce-Martos Jesús,Prieto-González Sergio,Gonzalez Raquel Aranega,Yoshida Akira,Nakashima Ran,Sato Shinji,Kimura Naoki,Kaneko Yuko,Tomaras Stylianos,Gromova Margarita Aleksandrovna,Aharonov Or,Hoff Leonardo Santos,Giannini Margherita,Maurier François,Campagne Julien,Meyer Alain,Nagy-Vincze Melinda,Langguth Daman,Limaye Vidya,Needham Merrilee,Srivastav Nilesh,Hudson Marie,Landon-Cardinal Océane,Shaharir Syahrul Sazliyana,Zuleta Wilmer Gerardo Rojas,Silva José António Pereira,Fonseca João Eurico,Zimba Olena,

Affiliation:

1. Rheumatology Department, Saint-Joseph University , Beirut, Lebanon

2. Rheumatology Department, Hotel-Dieu de France Hospital , Beirut, Lebanon

3. Laboratory of Clinical Research and Epidemiology, Faculty of Medicine, Mohammed V University , Rabat, Morocco

4. Department of Medicine, Health Sciences College, International University of Rabat (UIR) , Rabat, Morocco

5. Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow, India

6. Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK

7. Neurology, Manchester Centre for Clinical Neurosciences, Northern Care Alliance NHS Foundation Trust , Salford, UK

8. Maulana Azad Medical College , New Delhi, Delhi, India

9. Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals , Pune, India

10. Mahatma Gandhi Mission Medical College , Navi Mumbai, Maharashtra, India

11. Department of Medical Ecology and Hydroclimatology, Istanbul Faculty of Medicine, Istanbul University , Capa-Fatih, Istanbul, Turkey

12. Department of Rheumatology, Royal Melbourne Hospital , Parkville, VIC, Australia

13. Walter and Eliza Hall Institute of Medical Research , Parkville, VIC, Australia

14. Department of Medical Biology, University of Melbourne , Parkville, VIC, Australia

15. Division of Rheumatology, Mayo Clinic , Rochester, MN, USA

16. Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University , Szczecin, Poland

17. Rheumatology Department, Kasr Al Ainy School of Medicine, Cairo University , Cairo, Egypt

18. Rheumatology Department, Fauji Foundation Hospital , Rawalpindi, Pakistan

19. Medical Faculty, Sofia University St. Kliment Ohridski , Sofia, Bulgaria

20. Department of Internal Medicine, General Hospital, National Medical Center, ‘La Raza’, Instituto Mexicano del Seguro Social , Mexico City, Mexico

21. Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital , Stockholm, Sweden

22. Department of Rheumatology, Faculty of Medicine and Health, Örebro University , Örebro, Sweden

23. Centre for Rheumatic Diseases, King's College London , London, UK

24. Rheumatology Department, King's College Hospital , London, UK

25. Center for Outcomes Research, Department of Internal Medicine, University of Illinois College of Medicine , Peoria, IL, USA

26. NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust , Leeds, UK

27. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds , Leeds, UK

28. Departamento de Reumatología, Hospital de Especialidades Dr Antonio Fraga Mouret, IMSS, Centro Médico Nacional La Raza , Mexico City, Mexico

29. Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo , Sao Paulo, SP, Brazil

30. Medizinische Klinik 3 – Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Deutschland

31. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Bunkyo-ku, Tokyo, Japan

32. Southport and Ormskirk Hospital NHS Trust , Southport, UK

33. Rheumatology Division, IRCCS Policlinico San Matteo Foundation , Pavia, Lombardia, Italy

34. Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia , Pavia, Lombardy, Italy

35. Department of Rheumatology, University Hospital Zurich, University of Zurich , Zurich, Switzerland

36. National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester , Manchester, UK

37. Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust , Salford, UK

38. Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA

39. Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust , Wolverhampton, UK

40. City Hospital, Sandwell and West Birmingham Hospitals NHS Trust , Birmingham, UK

Abstract

Abstract Objectives We aimed to explore current practice and interregional differences in the treatment of idiopathic inflammatory myopathies (IIMs). We triangulated these observations considering countries' gross national income (GNI), disease subtypes, and symptoms using patient-reported information. Methods A cross-sectional ancillary analysis of the ‘COVID-19 vaccination in auto-immune disease’ (COVAD) e-survey containing demographic characteristics, IIM subtypes (DM, PM, IBM, anti-synthetase syndrome [ASSD], immune-mediated necrotizing myopathy [IMNM], overlap myopathies [OM]), current symptoms (surrogate for organ involvement) and treatments (corticosteroids [CS], immunomodulators [IM], i.e. antimalarials, immunosuppressants [IS], IVIG, biologic treatments and targeted-synthetic small molecules). Treatments were presented descriptively according to continents, GNI, IIM and organ involvement, and associated factors were analysed using multivariable binary logistic regressions. Results Of 18 851 respondents from 94 countries, 1418 with IIM were analysed (age 61 years, 62.5% females). DM (32.4%), IBM (24.5%) and OM (15.8%) were the most common subtypes. Treatment categories included IS (49.4%), CS (38.5%), IM (13.8%) and IVIG (9.4%). Notably, treatments varied across regions, GNI categories (IS mostly used in higher-middle income, IM in lower-middle income, IVIG and biologics largely limited to high-income countries), IIM subtypes (IS and CS associated with ASSD, IM with OM and DM, IVIG with IMNM, and biologic treatments with OM and ASSD) and disease manifestations (IS and CS with dyspnoea). Most inter-regional treatment disparities persisted after multivariable analysis. Conclusion We identified marked regional treatment disparities in a global cohort of IIM. These observations highlight the need for international consensus-driven management guidelines considering patient-centred care and available resources.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

Link

https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/kead250/50647025/kead250.pdf

Reference18 articles.

1. Idiopathic inflammatory myopathies: one year in review 2021;Cardelli;Clin Exp Rheumatol,2022

2. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups;Lundberg;Ann Rheum Dis,2017

3. Defining anti-synthetase syndrome: a systematic literature review;Zanframundo;Clin Exp Rheumatol,2022

4. Range and consistency of outcome measures reported in randomised trials in dermatomyositis: a systematic review;Kelly;Clin Exp Rheumatol,2022

5. Diagnosis and classification of idiopathic inflammatory myopathies;Lundberg;J Intern Med,2016

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