Osteophytes’ position in subjects with DISH and right-sided aorta: verification of the ‘aortic pulsation protective effect’ theory

Author:

Gliner-Ron Masha12,Bercovich Eyal3,Herman Amir4,Lidar Merav5,Militianu Daniela3,Eshed Iris1ORCID

Affiliation:

1. Department of Diagnostic Imaging, Sheba Medical Center, affiliated with the Sackler School of Medicine, Tel Aviv University , Tel Aviv

2. Department of Diagnostic Imaging, Hadassah Medical Center, affiliated with the Hebrew University of Jerusalem , Jerusalem

3. Department of Diagnostic Imaging, Rambam Medical Center , Haifa

4. Department of Orthopedic Surgery, Kaplan Medical Center , Rehovot

5. Rheumatology Unit, Sheba Medical Center, Affiliated with the Sackler School of Medicine, Tel Aviv University , Tel Aviv, Israel

Abstract

Abstract Objectives To validate in a large cohort with right-sided aorta the theory that thoracic right-sided flowing osteophytes in DISH results from a ‘protective’ effect of the pulsating descending left-sided thoracic aorta. Methods Chest CTs of patients with DISH and right-sided aorta and controls with DISH and left-sided aorta were evaluated and compared on each intervertebral space (IS) for the location of the aorta (right, left, centre) and the location of the osteophyte relative to the aorta (contralateral, ipsilateral, bilateral). Results The study and control cohorts included 31 and 35 subjects, respectively (male 22/9 and female 27/8; median age 64.8/65.3 years; P = 0.86). Osteophytes contralateral to the aorta’s location were recorded in the majority of ISs in both the study and control groups (47% and 60%, respectively; P > 0.05), while ipsilateral osteophytes were recorded in 6.9% and 7.7%, respectively (P = 0.002). Bilateral osteophytes located to the right and the left of the aorta were significantly more prevalent in the study group compared with the controls (17.2% and 5.4%, respectively; P = 0.04). Conclusions Aortic pulsation plays an important role in inhibiting the development of osteophytes and results in the majority of contralateral osteophytes on both right-sided and left-sided aortas. However, since both ipsilateral and bilateral osteophytes were not at all rare in both groups, other parameters, which are yet to be established, probably contribute to the location of osteophytes.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

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