Individuals with ACPA-negative clinically suspect arthralgia experience more symptom burden: is seronegative disease truly less severe?

Author:

Doumen Michaël12ORCID,Westhovens René12,Verschueren Patrick12

Affiliation:

1. Department of Development and Regeneration, KU Leuven , Leuven, Belgium

2. Rheumatology, University Hospitals Leuven , Leuven, Belgium

Publisher

Oxford University Press (OUP)

Reference10 articles.

1. Patient burden and joint-inflammation during development of RA from arthralgia: is it similar in ACPA-positive and ACPA-negative disease?;Khidir;Rheumatology (Oxford),2024

2. EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis;Van Steenbergen;Ann Rheum Dis,2017

3. Rheumatoid arthritis prevention in arthralgia: fantasy or reality?;van Steenbergen;Nat Rev Rheumatol,2023

4. Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial;Krijbolder;Lancet,2022

5. Abatacept in Individuals at Risk of Developing Rheumatoid Arthritis: results from the Arthritis Prevention in the Pre-clinical Phase of RA with Abatacept (APIPPRA). Trial [abstract];Cope;Arthritis Rheumatol,2023

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