Characteristics of and risk factors for COVID-19 breakthrough infections in idiopathic inflammatory myopathies: results from the COVAD study-Reference-Cited by-同舟云学术

Characteristics of and risk factors for COVID-19 breakthrough infections in idiopathic inflammatory myopathies: results from the COVAD study

Published:2024-03-02 Issue: Volume: Page:
ISSN:1462-0324
Container-title:Rheumatology
language:en
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Author:

Hoff Leonardo Santos¹,Ravichandran Naveen²^ORCID,Sen Parikshit³,Day Jessica⁴⁵⁶^ORCID,Joshi Mrudula⁷,Nune Arvind⁸^ORCID,Nikiphorou Elena⁹¹⁰,Saha Sreoshy¹¹,Tan Ai Lyn¹²¹³^ORCID,Shinjo Samuel Katsuyuki¹⁴,Ziade Nelly¹⁵¹⁶^ORCID,Velikova Tsvetelina¹⁷,Milchert Marcin¹⁸^ORCID,Jagtap Kshitij¹⁹,Parodis Ioannis²⁰²¹^ORCID,Gracia-Ramos Abraham Edgar²²^ORCID,Cavagna Lorenzo²³,Kuwana Masataka²⁴^ORCID,Knitza Johannes²⁵^ORCID,Chen Yi Ming²⁶²⁷,Makol Ashima²⁸,Agarwal Vishwesh²⁹,Patel Aarat³⁰,Pauling John D³¹³²^ORCID,Wincup Chris³³³⁴^ORCID,Barman Bhupen³⁵,Tehozol Erick Adrian Zamora³⁶,Serrano Jorge Rojas³⁷,Torre Ignacio García-De La³⁸,Colunga-Pedraza Iris J³⁹^ORCID,Merayo-Chalico Javier⁴⁰^ORCID,Chibuzo Okwara Celestine⁴¹,Katchamart Wanruchada⁴²,Goo Phonpen Akarawatcharangura⁴³,Shumnalieva Russka⁴⁴,El Kibbi Lina⁴⁵,Halabi Hussein⁴⁶,Vaidya Binit⁴⁷,Shaharir Syahrul Sazliyana⁴⁸,Hasan A T M Tanveer⁴⁹,Dey Dzifa⁵⁰,Gutiérrez Carlos Enrique Toro⁵¹,Caballero-Uribe Carlo V⁵²,Lilleker James B⁵³⁵⁴^ORCID,Salim Babur⁵⁵,Gheita Tamer⁵⁶^ORCID,Chatterjee Tulika⁵⁷,Distler Oliver⁵⁸^ORCID,Saavedra Miguel A⁵⁹,Chinoy Hector⁵³⁶⁰⁶¹^ORCID,Agarwal Vikas²^ORCID,Aggarwal Rohit⁶²^ORCID,Gupta Latika⁶³⁶⁴⁵³^ORCID, ,Singh Yogesh Preet,Ranjan Rajiv,Jain Avinash,Pandya Sapan C,Pilania Rakesh Kumar,Sharma Aman,M Manesh Manoj,Gupta Vikas,Kavadichanda Chengappa G,Patro Pradeepta Sekhar,Ajmani Sajal,Phatak Sanat,Goswami Rudra Prosad,Chowdhury Abhra Chandra,Mathew Ashish Jacob,Shenoy Padnamabha,Asranna Ajay,Bommakanti Keerthi Talari,Shukla Anuj,Pande Arunkumar R,Gaur Prithvi Sanjeevkumar,Mamadapur Mahabaleshwar,Ghodke Akanksha,Chandwar Kunal,Kadam Esha,Fazal Zoha Zahid,Kardeş Sinan,Cansu Döndü Üsküdar,Yıldırım Reşit,Gasparyan Armen Yuri,Giannini Margherita,Maurier François,Campagne Julien,Meyer Alain,Del Papa Nicoletta,Sambataro Gianluca,Fabiola Atzeni,Govoni Marcello,Parisi Simone,Bocci Elena Bartoloni,Sebastiani Gian Domenico,Fusaro Enrico,Sebastiani Marco,Quartuccio Luca,Franceschini Franco,Sainaghi Pier Paolo,Orsolini Giovanni,De Angelis Rossella,Danielli Maria Giovanna,Venerito Vincenzo,Grignaschi Silvia,Giollo Alessandro,Andreoli Laura,Lini Daniele,Alluno Alessia,Iannone Florenzo,Fornaro Marco,Traboco Lisa S,Wibowo Suryo Anggoro Kusumo,Loarce-Martos Jesús,Prieto-González Sergio,Aranega Raquel,Yoshida Akira,Nakashima Ran,Sato Shinji,Kimura Naoki,Kaneko Yuko,Gono Takahisa,Tomaras Stylianos,Proft Fabian Nikolai,Holzer Marie-Therese,Gromova Margarita Aleksandrovna,Aharonov Mr Or,Nagy-Vincze Melinda,Griger Zoltán,Schrieber Karen,Hmamouchi Ihsane,El bouchti Pr Imane,Baba Zineb,Ima-Edomwonyi Uyi,Dedeke Ibukunoluwa,Airenakho Emorinken,Madu Nwankwo Henry,Yerima Abubakar,Olaosebikan Hakeem,Becky A,Koussougbo Ouma Devi,Palalane Elisa,Langguth Daman,Limaye Vidya,Needham Merrilee,Srivastav Nilesh,Hudson Marie,Landon-Cardinal Océane,Zuleta Wilmer Gerardo Rojas,Arbeláez Álvaro,Cajas Javier,Silva José António Pereira,Fonseca João Eurico,Zimba Olena,Bohdana Doskaliuk,So Ho,Ugarte-Gil Manuel Francisco,Chinchay Lyn,Bernaola José Proaño,Pimentel Victorio,Fathi Hanan Mohamed,Mohammed Reem Hamdy A,Harifi Ghita,Fuentes-Silva Yurilís,Cabriza Karoll,Losanto Jonathan,Colaman Nelly,Cachafeiro-Vilar Antonio,Bautista Generoso Guerra,Ho Enrique Julio Giraldo,González Raúl,Nunez Lilith Stange,Cristian Vergara M,Báez Jossiell Then,Alonzo Hugo,Pastelin Carlos Benito Santiago,Salinas Rodrigo García,Obiols Alejandro Quiñónez,Chávez Nilmo,Ordóñez Andrea Bran,Argueta Sandra,Quijivix Daniel,Llerena Gil Alberto Reyes,Sierra-Zorita Radames,Arrieta Dina,Hidalgo Eduardo Romero,Saenz Ricardo,Morales Idania Escalante M , Roberto,Calapaqui Wendy,Quezada Ivonne,Arredondo Gabriela

Affiliation:

1. Department of Medicine, School of Medicine, Universidade Potiguar (UnP) , Natal, Brazil

2. Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences , Lucknow, India

3. Maulana Azad Medical College , New Delhi, Delhi, India

4. Department of Rheumatology, Royal Melbourne Hospital , Parkville, VIC, Australia

5. Walter and Eliza Hall Institute of Medical Research , Parkville, VIC, Australia

6. Department of Medical Biology, University of Melbourne , Parkville, VIC, Australia

7. Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals , Pune, India

8. Department of Rheumatology, Southport and Ormskirk Hospital NHS Trust , Southport, UK

9. Centre for Rheumatic Diseases, King’s College London , London, UK

10. Rheumatology Department, King’s College Hospital , London, UK

11. Mymensingh Medical College , Mymensingh, Bangladesh

12. NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust , Leeds, UK

13. Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds , Leeds, UK

14. Division of Rheumatology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo , Sao Paulo, SP, Brazil

15. Rheumatology Department, Saint-Joseph University , Beirut, Lebanon

16. Rheumatology Department, Hotel-Dieu de France Hospital , Beirut, Lebanon

17. Medical Faculty, Sofia University St Kliment Ohridski , Sofia, Bulgaria

18. Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin , Szczecin, Poland

19. Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital , Mumbai, Maharashtra, India

20. Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital , Stockholm, Sweden

21. Department of Rheumatology, Faculty of Medicine and Health, Örebro University , Örebro, Sweden

22. Department of Internal Medicine, General Hospital, National Medical Center, La Raza, Instituto Mexicano del Seguro Social , Mexico City, Mexico

23. Rheumatology Unit, Dipartimento di Medicine Interna e Terapia Medica, Università degli studi di Pavia , Pavia, Lombardy, Italy

24. Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine , Tokyo, Japan

25. Medizinische Klinik 3—Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg , Erlangen, Deutschland

26. Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital , Taichung City, Taiwan

27. Department of Medical Research, Taichung Veterans General Hospital , Taichung, Taiwan

28. Division of Rheumatology, Mayo Clinic , Rochester, MN, USA

29. Mahatma Gandhi Mission Medical College, Navi Mumbai , Maharashtra, India

30. Bon Secours Rheumatology Center and Division of Pediatric Rheumatology, Department of Pediatrics, University of Virginia School of Medicine , Charlottesville, VA, USA

31. Bristol Medical School Translational Health Sciences, University of Bristol , Bristol, UK

32. Department of Rheumatology, North Bristol NHS Trust , Bristol, UK

33. Department of Rheumatology, Division of Medicine, Rayne Institute, University College London , London, UK

34. Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH, GOSH , London, UK

35. Department of General Medicine, All India Institute of Medical Sciences (AIIMS) , Guwahati, India

36. Rheumatology, Medical Care & Research, Centro Medico Pensiones Hospital, Instituto Mexicano del Seguro Social Delegación Yucatán , Yucatán, Mexico

37. Rheumatologist and Clinical Investigator, Interstitial Lung Disease and Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias , Mexico City, Mexico

38. Departamento de Inmunología y Reumatología, Hospital General de Occidente and Universidad de Guadalajara , Guadalajara, Jalisco, Mexico

39. Rheumatology, Hospital Universitario Dr Jose Eleuterio Gonzalez , Monterrey, Mexico

40. Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , Mexico City, Mexico

41. Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla/University of Nigeria , Enugu Campus, Enugu, Nigeria

42. Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University , Bangkok, Thailand

43. Department of Medicine, Queen Savang Vadhana Memorial Hospital , Chonburi, Thailand

44. Department of Rheumatology, Clinic of Rheumatology, University Hospital “St Ivan Rilski”, Medical University-Sofia , Sofia, Bulgaria

45. Rheumatology Unit, Internal Medicine Department, Specialized Medical Center , Riyadh, Saudi Arabia

46. Department of Internal Medicine, Section of Rheumatology, King Faisal Specialist Hospital and Research Center , Jeddah, Saudi Arabia

47. National Center for Rheumatic Diseases (NCRD) , Ratopul, Kathmandu, Nepal

48. Faculty of Medicine, Universiti Kebangsaan Malaysia , Cheras, Kuala Lumpur, Malaysia

49. Department of Rheumatology, Enam Medical College & Hospital , Dhaka, Bangladesh

50. Rheumatology Unit, Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences , Accra, Ghana

51. General Director, Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali , Valle del Cauca, Colombia

52. Department of Medicine, Hospital Universidad del Norte , Barranquilla, Atlantico, Colombia

53. Division of Musculoskeletal and Dermatological Sciences, Centre for Musculoskeletal Research, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester , Manchester, UK

54. Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust , Salford, UK

55. Rheumatology Department, Fauji Foundation Hospital , Rawalpindi, Pakistan

56. Rheumatology Department, Kasr Al Ainy School of Medicine, Cairo University , Cairo, Egypt

57. Department of Internal Medicine, University of Illinois College of Medicine at Peoria , Illinois, USA

58. Department of Rheumatology, University Hospital Zürich, University of Zürich , Zürich, Switzerland

59. Departamento de Reumatología, Hospital de Especialidades Dr Antonio Fraga Mouret, Centro Médico Nacional La Raza, IMSS , Mexico City, Mexico

60. National Institute for Health Research Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, The University of Manchester , Manchester, UK

61. Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust , Salford, UK

62. Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA

63. Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust , Wolverhampton, UK

64. City Hospital, Sandwell and West Birmingham Hospitals NHS Trust , Birmingham, UK

Abstract

Abstract Objectives The objective of this study was to explore the prevalence, characteristics and risk factors of COVID-19 breakthrough infections (BIs) in idiopathic inflammatory myopathies (IIMs) using data from the COVID-19 Vaccination in Autoimmune Diseases (COVAD) study. Methods A validated patient self-reporting e-survey was circulated by the COVAD study group to collect data on COVID-19 infection and vaccination in 2022. BIs were defined as COVID-19 occurring ≥14 days after two vaccine doses. We compared BI characteristics and severity among patients with IIMs, patients with other autoimmune rheumatic and non-rheumatic diseases (AIRD, nrAID), and healthy controls (HCs). Multivariable Cox regression models were used to assess the risk factors for BI, severe BI ,and hospitalizations among patients with IIMs. Results Among the 9449 included responses, BIs occurred in 1447 respondents (15.3%). The median age was 44 years [interquartile range (IQR) 21], 77.4% were female, and 182 BIs (12.9%) occurred among the 1406 patients with IIMs. Multivariable Cox regression among the data for patients with IIMs showed increasing age to be a protective factor for BIs [hazard ratio (HR) = 0.98, 95% CI = 0.97–0.99], and HCQ and SSZ use were risk factors (HR = 1.81, 95% CI = 1.24–2.64, and HR = 3.79, 95% CI = 1.69–8.42, respectively). Glucocorticoid use was a risk factor for a severe BI (HR = 3.61, 95% CI = 1.09–11.8). Non-white ethnicity (HR = 2.61, 95% CI = 1.03–6.59) was a risk factor for hospitalization. Compared with other groups, patients with IIMs required more supplemental oxygen therapy (IIMs = 6.0% vs AIRDs = 1.8%, nrAIDs = 2.2% and HCs = 0.9%), intensive care unit admission (IIMs = 2.2% vs AIRDs = 0.6%, nrAIDs and HCs = 0%), advanced treatment with antiviral or monoclonal antibodies (IIMs = 34.1% vs AIRDs = 25.8%, nrAIDs = 14.6% and HCs = 12.8%) and had more hospitalization (IIMs = 7.7% vs AIRDs = 4.6%, nrAIDs = 1.1% and HCs = 1.5%). Conclusion Patients with IIMs are susceptible to severe COVID-19 BIs. Age and immunosuppressive treatments were related to the risk of BIs.

Funder

National Institution for Health Research Manchester Biomedical Research Centre Funding Scheme

NHS

National Institute for Health Research

Department of Health

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/rheumatology/advance-article-pdf/doi/10.1093/rheumatology/keae128/56820490/keae128.pdf

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