SARS-CoV-2 infection in patients with primary Sjögren syndrome: characterization and outcomes of 51 patients-Reference-Cited by-同舟云学术

SARS-CoV-2 infection in patients with primary Sjögren syndrome: characterization and outcomes of 51 patients

Published:2020-12-14 Issue:6 Volume:60 Page:2946-2957
ISSN:1462-0324
Container-title:Rheumatology
language:en
Short-container-title:

Author:

Brito-Zerón Pilar¹²,Melchor Sheila³^ORCID,Seror Raphaèle⁴,Priori Roberta⁵,Solans Roser⁶,Kostov Belchin⁷⁸⁹,Baldini Chiara¹⁰,Carubbi Francesco¹¹,Callejas Jose Luis¹²,Guisado-Vasco Pablo¹³,Hernández-Molina Gabriela¹⁴,Pasoto Sandra G¹⁵,Valim Valeria¹⁶,Sisó-Almirall Antoni⁷⁸¹⁷,Mariette Xavier¹⁸,Carreira Patricia³,Ramos-Casals Manuel¹¹⁷¹⁹,Brito-Zerón P,Morcillo C,Brito-Zerón P,Flores-Chávez A,Ramos-Casals M,Acar-Denizli N,Horvath I F,Szanto A,Tarr T,Seror R,Mariette X,Mandl T,Olsson P,Li X,Xu B,Baldini C,Bombardieri S,Gottenberg J E,Gandolfo S,De Vita S,Priori R,Giardina F,Hernandez-Molina G^ORCID,Sánchez-Guerrero J,Kruize A A,Hinrichs A,Valim V,Isenberg D,Solans R,Rischmueller M,Downie-Doyle S,Kwok S-K,Park S-H,Nordmark G,Suzuki Y,Kawano M,Giacomelli R,Devauchelle-Pensec V,Saraux A,Hofauer B,Knopf A,Bootsma H,Vissink A,Morel J,Vollenveider C,Atzeni F,Retamozo S,Moça Trevisano V,Armagan B,Kilic L,Kalyoncu U,Pasoto S G,Kostov B,Sisó-Almirall A,Consani-Fernández S,Carubbi F,Callejas J L,López-Dupla M,Pérez-Alvarez R,Akasbi M,Guisado-Vasco P,Sánchez I,

Affiliation:

1. Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Barcelona, Spain

2. Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA- Sanitas, Barcelona, Spain

3. Servicio de Reumatologia, Hospital Universitario, 12 de Octubre, Madrid, Spain

4. Department of Rheumatology, National Reference Center for Sjögren Syndrome and Rare Autoimmune Diseases, Université Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, AP-HP, Le Kremlin Bicêtre, France

5. Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, Sapienza University of Rome, Rome, Italy

6. Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain

7. Primary Care Centre Les Corts, Consorci d’Atenció Primària de Salut Barcelona Esquerra (CAPSBE), Barcelona, Spain

8. Primary healthcare transversal research group, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

9. Department of Statistics and Operations Research, Universitat Politècnica de Catalunya (UPC), Barcelona, Spain

10. Rheumatology Unit, University of Pisa, Pisa, Italy

11. COVID-19 Medical Unit, San Salvatore Hospital, Department of Medicine, ASL1 Avezzano-Sulmona-L’Aquila, L’Aquila, Italy

12. Department of Internal Medicine, Hospital San Cecilio, Granada, Spain

13. Department of Internal Medicine, Hospital Universitario Quironsalud, Madrid, Spain

14. Immunology and Rheumatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico

15. Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil

16. Department of Medicine, Federal University of Espírito Santo, Vitória, Brazil

17. Department of Medicine, Universitat de Barcelona, Barcelona, Spain

18. Centre for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Saclay, Le Kremlin-Bicêtre, Université Paris-Saclay, INSERM, Paris, France

19. Department of Autoimmune Diseases, ICMiD, Hospital Clínic, Barcelona, Spain

Abstract

Abstract Objective To analyse the prognosis and outcomes of SARS-CoV-2 infection in patients with primary SS. Methods We searched for patients with primary SS presenting with SARS-CoV-2 infection (defined following and according to the European Centre for Disease Prevention and Control guidelines) among those included in the Big Data Sjögren Registry, an international, multicentre registry of patients diagnosed according to the 2002/2016 classification criteria. Results A total of 51 patients were included in the study (46 women, mean age at diagnosis of infection of 60 years). According to the number of patients with primary SS evaluated in the Registry (n = 8211), the estimated frequency of SARS-CoV-2 infection was 0.62% (95% CI 0.44, 0.80). All but two presented with symptoms suggestive of COVID-19, including fever (82%), cough (57%), dyspnoea (39%), fatigue/myalgias (27%) and diarrhoea (24%), and the most frequent abnormalities included raised lactate dehydrogenase (LDH) (88%), CRP (81%) and D-dimer (82%) values, and lymphopenia (70%). Infection was managed at home in 26 (51%) cases and 25 (49%) required hospitalization (five required admission to ICU, four died). Compared with patients managed at home, those requiring hospitalization had higher odds of having lymphopenia as laboratory abnormality (adjusted OR 21.22, 95% CI 2.39, 524.09). Patients with comorbidities had an older age (adjusted OR 1.05, 95% CI 1.00, 1.11) and showed a risk for hospital admission six times higher than those without (adjusted OR 6.01, 95% CI 1.72, 23.51) in the multivariate analysis. Conclusion Baseline comorbidities were a key risk factor for a more complicated COVID-19 in patients with primary SS, with higher rates of hospitalization and poor outcomes in comparison with patients without comorbidities.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

Link

http://academic.oup.com/rheumatology/article-pdf/60/6/2946/38695112/keaa748.pdf

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