The incidence and prevalence of juvenile idiopathic arthritis differs between ethnic groups in England

Author:

Beesley Richard P1ORCID,Hyrich Kimme L12ORCID,Humphreys Jenny H12

Affiliation:

1. Centre for Epidemiology Versus Arthritis, The University of Manchester, Manchester Academic Health Science Centre , Manchester, UK

2. National Institute of Health Research, Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust , Manchester, UK

Abstract

Abstract Objectives JIA is a heterogeneous group of rare autoimmune disorders characterized by chronic joint inflammation of unknown aetiology with onset under 16 years. Accurate estimates of disease rates help understand impacts on individuals and society, and provide evidence for health service planning and delivery. This study aimed to produce the first national estimates of incidence and prevalence by ethnic group using electronic health records. Methods Data from the Clinical Practice Research Datalink Aurum, a primary care electronic health record database in England, were used to estimate the incidence and prevalence of JIA by ethnic group amongst children and young people aged under 16 years between 2003 and 2018, with cases validated using Hospital Episode Statistics. χ2 was used to test the difference in proportions compared with the ethnic distribution of England. Results A total of 424 incident cases of JIA were identified, 389 validated using Hospital Episode Statistics records. Incidence of JIA was higher amongst those of white ethnic group (6.2 per 100 000 population) compared with mixed (3.0 per 100 000), Asian (2.7 per 100 000) and Black (2.9 per 100 000) communities. The ethnic group distribution of cases differed significantly compared with the general population (P < 0.0001). Conclusion The incidence and prevalence of JIA differs between ethnic groups, and is different from the general population. This is likely to be due to a combination of genetic and equity factors. Further research to understand the underlying cause of these differences is important to enable targeted interventions and appropriate service provision.

Funder

NIHR

Centre for Epidemiology Versus Arthritis

Academy of Medical Sciences Starter Grant for Clinical Lecturers

NIHR Manchester Biomedical Research Centre

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

Reference22 articles.

1. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001;Petty;J Rheumatol,2004

2. Long-term outcome in patients with juvenile idiopathic arthritis;Minden;Arthritis Rheum,2002

3. Experiences of employment among young people with juvenile idiopathic arthritis: a qualitative study;Hanson;Disabil Rehabil,2018

4. Prevalence and incidence of juvenile idiopathic arthritis: a systematic review;Thierry;Joint Bone Spine,2014

5. Incidence and prevalence of Juvenile Idiopathic Arthritis in the United Kingdom 2000-2018: results from the Clinical Practice Research Datalink;Costello;Rheumatology (Oxford),2021

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