Impaired IRE1α/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren’s syndrome patients

Author:

Sepúlveda Denisse1,Barrera María-José1,Castro Isabel12,Aguilera Sergio3,Carvajal Patricia1,Lagos Carolina1,González Sergio4,Albornoz Nicolás1,Bahamondes Verónica12,Quest Andrew F G156,Urzúa Ulises1,Molina Claudio4,Leyton Cecilia12,Hermoso Marcela A7,González María-Julieta1

Affiliation:

1. Programa de Biología Celular y Molecular, Instituto de Ciencias Biomédicas (ICBM), Santiago, Chile

2. Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile, Santiago, Chile

3. Departamento de Reumatología, Clínica IndisaSantiago, Chile

4. Departamento de Patología Oral, Escuela de Odontología, Facultad de Ciencias, Universidad Mayor, Santiago, Chile

5. Center for Molecular Studies of the Cell (CEMC), Universidad de Chile, Santiago, Chile

6. Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile, Santiago, Chile

7. Programa de Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile, Santiago, Chile

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Rheumatology

Reference50 articles.

1. Pathogenesis of Sjogren's syndrome: what we know and what we should learn;Tzioufas;J Autoimmun,2012

2. Oral dryness in Sjogren's syndrome patients. Not just a question of water;Castro;Autoimmun Rev,2013

3. Structure and function of the cell surface (tethered) mucins;Hattrup;Annu Rev Physiol,2008

4. The many functions of the endoplasmic reticulum chaperones and folding enzymes;Halperin;IUBMB Life,2014

5. Proteostasis control by the unfolded protein response;Hetz;Nat Cell Biol,2015

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