1. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK
2. NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton, Southampton, UK
3. MRC Lifecourse Epidemiology Unit, Southampton University, Southampton, UK
4. GREMPAL Research Group, Idiap Jordi Gol and CIBERFes, Universitat Autonoma de Barcelona and Instituto de Salud Carlos III, Barcelona, Spain