Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model-Reference-Cited by-同舟云学术

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Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model

Published:2015-06-01 Issue:17 Volume:24 Page:4780-4791
ISSN:0964-6906
Container-title:Human Molecular Genetics
language:en
Short-container-title:Hum. Mol. Genet.

Author:

Aikawa Tomonori,Mogushi Kaoru,Iijima-Tsutsui Kumiko,Ishikawa Kinya,Sakurai Miyano,Tanaka Hiroshi,Mizusawa Hidehiro,Watase Kei

Funder

Grants-in-Aid for Scientific Research

Grant-in-Aid for Scientific Research

Foundation of Synapse and Neurocircuit Pathology

Grant-in-Aid for Young Scientists

Ministry of Education, Culture, Sports, Science and Technology of Japan

Core Research for Evolutional Science and Technology (CREST)

Japan Science and Technology Agency

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Link

http://academic.oup.com/hmg/article-pdf/24/17/4780/13940809/ddv202.pdf

Reference41 articles.

1. Trinucleotide repeat disorders;Orr;Annu. Rev. Neurosci.,2007

2. The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7

3. Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the α1A-voltage-dependent calcium channel

4. Japanese Families with Autosomal Dominant Pure Cerebellar Ataxia Map to Chromosome 19p13.1-p13.2 and Are Strongly Associated with Mild CAG Expansions in the Spinocerebellar Ataxia Type 6 Gene in Chromosome 19p13.1

5. Spinocerebellar ataxia type 6 knockin mice develop a progressive neuronal dysfunction with age-dependent accumulation of mutant CaV2.1 channels

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3. Motor deficits are associated with increased glial cell activation in the hypothalamus and cerebellum of young rats subjected to cerebral palsy;Brain Research;2023-09

4. Proinflammatory activation of microglia in the cerebellum hyperexcites Purkinje cells to trigger ataxia;Pharmacological Research;2023-05

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