The pleiotropic effects of statins inrheumatoid arthritis

Author:

Aminifar Elham1,Tavakkol Afshari Haleh Sadat2,Sathyapalan Thozhukat3ORCID,Abbasifard Mitra45ORCID,Sahebkar Amirhossein67ORCID

Affiliation:

1. Student Research Committee, Islamic Azad University, Mashhad Branch , Mashhad , Iran

2. Department of Biology, Mashhad Branch, Islamic Azad University , Mashhad , Iran

3. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull , Hull , UK

4. Immunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences , Rafsanjan , Iran

5. Department of Internal Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences , Rafsanjan , Iran

6. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences , Mashhad , Iran

7. Applied Biomedical Research Center, Mashhad University of Medical Sciences , Mashhad , Iran

Abstract

AbstractObjectivesRheumatoid arthritis (RA) is an inflammatory and autoimmune disease. Studies over the past two decades suggest that statins have a beneficial impact on the complications associated with RA. These complications include RA disease activity and risk for cardiovascular diseases (CVD). This review aims to discuss the efficacy of statin therapy in RA.Key findingsThe current evidence suggests that statins' immunomodulatory and antioxidant properties significantly reduce disease activity and inflammatory response in patients with RA. In RA patients, the risk of CVD is reduced by statin treatment, and statin discontinuation is associated with an increased cardiovascular disease risk.SummaryThe combined effect of statins on improving vascular function, lowering lipid levels, and reducing inflammation in RA patients is responsible for the decreased all-cause mortality in statin users. Further clinical studies are needed to ensure the therapeutic efficacy of statins in patients with RA.

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

Reference120 articles.

1. Clustering of cardiovascular risk factors in rheumatoid arthritis: the rationale for using statins;Gazi;Clin Exp Rheumatol,2007

2. Epidemiology of adult rheumatoid arthritis;Alamanos;Autoimmun Rev,2005

3. Cardiovascular disease in rheumatoid arthritis;Kaplan;Curr Opin Rheumatol,2006

4. Rheumatoid arthritis: a disease associated with accelerated atherogenesis.;Gonzalez-Gay,2005

5. Therapies for bone R;Smolen;Lancet,2016

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3