A Meta-Analysis of Neural Correlates of Reward Anticipation in Individuals at Clinical Risk for Schizophrenia

Author:

Zeng Jianguang1,Yan Jiangnan1,You Lantao1,Liao Tingting2,Luo Ya3,Cheng Bochao4ORCID,Yang Xun2

Affiliation:

1. School of Economics and Business Administration, Chongqing University , Chongqing , China

2. School of Public Policy and Administration, Chongqing University , Chongqing , China

3. Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital of Sichuan University , Chengdu , China

4. Department of Radiology, West China Second University Hospital of Sichuan University , Chengdu , China

Abstract

AbstractBackgroundAberrant striatal responses to reward anticipation have been observed in schizophrenia. However, it is unclear whether these dysfunctions predate the onset of psychosis and whether reward anticipation is impaired in individuals at clinical high risk for schizophrenia (CHR).MethodsTo examine the neural correlates of monetary anticipation in the prodromal phase of schizophrenia, we performed a whole-brain meta-analysis of 13 functional neuroimaging studies that compared reward anticipation signals between CHR individuals and healthy controls (HC). Three databases (PubMed, Web of Science, and ScienceDirect) were systematically searched from January 1, 2000, to May 1, 2022.ResultsThirteen whole-brain functional magnetic resonance imaging studies including 318 CHR individuals and 426 HC were identified through comprehensive literature searches. Relative to HC, CHR individuals showed increased brain responses in the medial prefrontal cortex and anterior cingulate cortex and decreased activation in the mesolimbic circuit, including the putamen, parahippocampal gyrus, insula, cerebellum, and supramarginal gyrus, during reward anticipation.ConclusionsOur findings in the CHR group confirmed the existence of abnormal motivational-related activation during reward anticipation, thus demonstrating the pathophysiological characteristics of the risk populations. These results have the potential to lead to the early identification and more accurate prediction of subsequent psychosis as well as a deeper understanding of the neurobiology of high-risk state of psychotic disorder.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities of China

Graduate Research and Innovation Foundation of Chongqing, China

Venture and Innovation Support Program for Chongqing Overseas Returnees

Social Science Foundation of Chongqing

Chongqing University

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk;Journal of Psychiatry and Brain Science;2023

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