Event-Related Potential Markers of Suicidality in Adolescents

Author:

Doruk Camsari Deniz1,Lewis Charles P12ORCID,Sonmez Ayse Irem12,Ozger Can1,Fatih Parmis13,Yuruk Deniz1,Shekunov Julia1,Vande Voort Jennifer L1,Croarkin Paul E1ORCID

Affiliation:

1. Department of Psychiatry and Psychology, Mayo Clinic , Rochester, Minnesota , USA

2. Department of Psychiatry and Behavioral Sciences, University of Minnesota , Minneapolis, Minnesota , USA

3. Department of Psychiatry, Rush University , Chicago, Illinois , USA

Abstract

Abstract Background Implicit cognitive markers may assist with the prediction of suicidality beyond clinical risk factors. The aim of this study was to investigate neural correlates associated with the Death/Suicide Implicit Association Test (DS-IAT) via event-related potentials (ERP) in suicidal adolescents. Methods Thirty inpatient adolescents with suicidal ideations and behaviors (SIBS) and 30 healthy controls from the community were recruited. All participants underwent 64-channel electroencephalography, DS-IAT, and clinical assessments. Hierarchical generalized linear models with spatiotemporal clustering were used to identify significant ERPs associated with the behavioral outcome of DS-IAT (D scores) and group differences. Results Behavioral results (D scores) showed that the adolescents with SIBS had stronger implicit associations between “death” and “self” than the healthy group (P = .02). Within adolescents with SIBS, participants with stronger implicit associations between “death” and “self” reported more difficulty in controllability of suicidal ideation in the past 2 weeks based on the Columbia-Suicide Severity Rating Scale (P = .03). For the ERP data, the D scores and N100 component over the left parieto-occipital cortex had significant correlations. Significant group differences without behavioral correlation were observed for a second N100 cluster (P = .01), P200 (P = .02), and late positive potential (5 clusters, all P ≤ .02). Exploratory predictive models combining both neurophysiological and clinical measures distinguished adolescents with SIBS from healthy adolescents. Conclusions Our results suggest that N100 may be a marker of attentional resources involved in the distinction of stimuli that are congruent or incongruent to associations between death and self. Combined clinical and ERP measures may have utility in future refinements of assessment and treatment approaches for adolescents with suicidality.

Funder

Mayo Clinic Clinical Translational Science

Brain and Behavior Research Foundation NARSAD Young Investigator Award

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

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