Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test

Author:

Dortet Laurent1234ORCID,Bonnin Remy A34,Pennisi Ivana1,Gauthier Lauraine234,Jousset Agnès B234,Dabos Laura3,Furniss R Christopher D1,Mavridou Despoina A I1,Bogaerts Pierre5,Glupczynski Youri5,Potron Anais46,Plesiat Patrick46,Beyrouthy Racha47,Robin Frédéric47,Bonnet Richard47,Naas Thierry234,Filloux Alain1ORCID,Larrouy-Maumus Gerald1ORCID

Affiliation:

1. MRC Centre for Molecular Bacteriology and Infection, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, UK

2. Department of Bacteriology-Hygiene, Bicêtre Hospital, Assistance Publique - Hôpitaux de Paris, Le Kremlin-Bicêtre, France

3. EA7361 ‘Structure, dynamic, function and expression of broad spectrum β-lactamases’, Paris-Sud University, Paris Saclay University, LabEx Lermit, Faculty of Medicine, Le Kremlin-Bicêtre, France

4. French National Reference Center for Antibiotic Resistance, Le Kremlin-Bicêtre, France

5. Laboratory of Clinical Microbiology, Belgian National Reference Center for Monitoring Antimicrobial Resistance in Gram-negative Bacteria, CHU UCL Namur, Yvoir, Belgium

6. Bacteriology Unit, University Hospital of Besançon, Besançon, France

7. Bacteriology Unit, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France

Funder

University Paris-Sud

Laboratory of Excellence in Research on Medication and Innovative Therapeutics

French National Research Agency

European Union’s Horizon 2020

University Paris Sud

MRC Career Development Award

MRC Confidence in Concept Award

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology,Microbiology (medical)

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