Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors

Author:

Osorio Giovana12,Zulueta-Dorado Teresa3,González-Rodríguez Patricia1,Bernabéu-Wittel José2,Conejo-Mir Julian2,Ramírez-Lorca Reposo1,Echevarría Miriam1

Affiliation:

1. Department of Medical Physiology and Biophysics, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain

2. Department of Dermatology, Hospital Universitario Virgen del Rocío, Seville, Spain

3. Department of Pathological Anatomy, Hospital Universitario Virgen del Rocío, Seville, Spain

Abstract

Abstract Objectives Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer. Methods Analysis of AQP1 and AQP3 expression by immunohistochemistry of 72 skin biopsy specimens from melanocytic skin tumors, nonmelanocytic tumors, or healthy samples. Results AQP1 showed strong labeling in 100% of benign common melanocytic nevi. Small blood vessels, stroma, and melanophages surrounding different types of melanomas tumors also were positive. Tumoral melanocytes in atypical nevi and melanomas were negative for AQP1. AQP3 showed strong labeling in 100% of melanocytic nevi, 100% of atypical melanocytic nevi, and 100% of melanomas. In all basal cell carcinomas and squamous cell carcinomas, staining for AQP3 was positive. Conclusions To our knowledge, this work represents the first demonstration of AQP1/AQP3 expression in human melanocytic skin tumors. More studies are needed to understand the underlying molecular mechanisms of expression of both AQPs in melanocytic tumors and their potential as molecular therapeutic targets.

Funder

Instituto de Salud Carlos III

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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