Building a collaborative cloud platform to accelerate heart, lung, blood, and sleep research
Author:
Ahalt Stan1, Avillach Paul2ORCID, Boyles Rebecca3, Bradford Kira13, Cox Steven1, Davis-Dusenbery Brandi4, Grossman Robert L5ORCID, Krishnamurthy Ashok1, Manning Alisa6, Paten Benedict7ORCID, Philippakis Anthony6, Borecki Ingrid8, Chen Shu Hui9, Kaltman Jon9, Ladwa Sweta10, Schwartz Chip11, Thomson Alastair9, Davis Sarah1, Leaf Alison4, Lyons Jessica2, Sheets Elizabeth7, Bis Joshua C12, Conomos Matthew13, Culotti Alessandro6, Desain Thomas2, Digiovanna Jack4, Domazet Milan4, Gogarten Stephanie13ORCID, Gutierrez-Sacristan Alba2ORCID, Harris Tim7, Heavner Ben13, Jain Deepti13, O'Connor Brian14, Osborn Kevin7, Pillion Danielle2, Pleiness Jacob15, Rice Ken13, Rupp Garrett4, Serret-Larmande Arnaud2, Smith Albert15, Stedman Jason P2, Stilp Adrienne13ORCID, Barsanti Teresa14, Cheadle John3, Erdmann Christopher1, Farlow Brandy1, Gartland-Gray Allie3, Hayes Julie1, Hiles Hannah1, Kerr Paul1, Lenhardt Chris1, Madden Tom3, Mieczkowska Joanna O1ORCID, Miller Amanda1, Patton Patrick1, Rathbun Marcie3, Suber Stephanie1, Asare Joe3
Affiliation:
1. Renaissance Computing Institute, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina, USA 2. Department of Biomedical Informatics, Harvard Medical School , Boston, Massachusetts, USA 3. RTI International , Triangle Park, North Carolina, USA 4. Velsera , Boston, Massachusetts, USA 5. University of Chicago , Chicago, Illinois, USA 6. The Broad Institute of MIT and Harvard , Cambridge, Massachusetts, USA 7. UC Santa Cruz Genomics Institute, University of California, Santa Cruz , Santa Cruz, California, USA 8. Independent Consultant, BioData Catalyst Steering Committee Chair , St. Louis, Missouri, USA 9. National Heart, Lung, and Blood Institute, NIH , Bethesda, Maryland, USA 10. Axle Informatics , Rockville, Maryland, USA 11. Coresoft, LLC , Gaithersburg, Maryland, USA 12. Department of Medicine, University of Washington , Seattle, Washington, USA 13. Department of Biostatistics, University of Washington , Seattle, Washington, USA 14. Nimbus Informatics , San Jose, California, USA 15. Department of Biostatistics, University of Michigan School of Public Health , Ann Arbor, Michigan, USA
Abstract
Abstract
Research increasingly relies on interrogating large-scale data resources. The NIH National Heart, Lung, and Blood Institute developed the NHLBI BioData CatalystⓇ (BDC), a community-driven ecosystem where researchers, including bench and clinical scientists, statisticians, and algorithm developers, find, access, share, store, and compute on large-scale datasets. This ecosystem provides secure, cloud-based workspaces, user authentication and authorization, search, tools and workflows, applications, and new innovative features to address community needs, including exploratory data analysis, genomic and imaging tools, tools for reproducibility, and improved interoperability with other NIH data science platforms. BDC offers straightforward access to large-scale datasets and computational resources that support precision medicine for heart, lung, blood, and sleep conditions, leveraging separately developed and managed platforms to maximize flexibility based on researcher needs, expertise, and backgrounds. Through the NHLBI BioData Catalyst Fellows Program, BDC facilitates scientific discoveries and technological advances. BDC also facilitated accelerated research on the coronavirus disease-2019 (COVID-19) pandemic.
Funder
National Institutes of Health National Heart, Lung, and Blood Institute TOPMed Data Coordinating Center
Publisher
Oxford University Press (OUP)
Subject
Health Informatics
Reference40 articles.
1. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program;Taliun,2021
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