Inference-based correction of multi-site height and weight measurement data in the All of Us research program

Abstract

Abstract Objective Measurement and data entry of height and weight values are error prone. Aggregation of medical record data from multiple sites creates new challenges prompting the need to identify and correct errant values. We sought to characterize and correct issues with height and weight measurement values within the All of Us (AoU) Research Program. Materials and Methods Using the AoU Researcher Workbench, we assessed site-level measurement value distributions to infer unit types. We also used plausibility checks with exceptions for conditions with possible outlier values, eg obesity, and assessed for excess deviation within individual participant’s records. Results 15.8% of height and 22.4% of weight values had missing unit type information. Discussion We identified several measurement unit related issues: the use of different units of measure within and between sites, missing units, and incorrect labeling of units. Failure to account for these in patient data repositories may lead to erroneous study results and conclusions. Conclusion Discrepancies in height and weight measurement data may arise from missing or mislabeled units. Using site- and participant-level analyses while accounting for outlier value-associated clinical conditions, we can infer measurement units and apply corrections. These methods are adaptable and expandable within AoU and other data repositories.