Enhancing antibody-dependent cell-mediated cytotoxicity: a strategy for improving antibody-based immunotherapy-Reference-Cited by-同舟云学术

Enhancing antibody-dependent cell-mediated cytotoxicity: a strategy for improving antibody-based immunotherapy

Published:2018-06 Issue:1 Volume:1 Page:7-12
ISSN:2516-4236
Container-title:Antibody Therapeutics
language:en
Short-container-title:

Author:

Zahavi David¹^ORCID,AlDeghaither Dalal¹,O’Connell Allison¹,Weiner Louis M¹

Affiliation:

1. Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center,3800 Reservoir Rd NW, Washington, DC 20007, USA

Abstract

ABSTRACT The targeting of surface antigens expressed on tumor cells by monoclonal antibodies (mAbs) has revolutionized cancer therapeutics. One mechanism of action of antibody-based immunotherapy is the activation of immune effector cells to mediate antibody-dependent cell-mediated cytotoxicity (ADCC). This review will summarize the process of ADCC, its important role in the efficacy of mAb therapy, how to measure it, and finally future strategies for antibody design that can take advantage of it to improve clinical performance.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Immunology,Immunology and Allergy

Link

http://academic.oup.com/abt/article-pdf/1/1/7/34926959/tby002.pdf

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