Genetic Evaluation for Hereditary Cancer Syndromes Among African Americans: A Critical Review

Author:

Khan Ambreen1ORCID,Rogers Charles R2,Kennedy Carson D2,Lopez AnaMaria3,Jeter Joanne1

Affiliation:

1. Family Cancer Assessment Clinic, Huntsman Cancer Institute, Salt Lake City, UT, USA

2. Department of Family and Preventive Medicine, University of Utah School of Medicine, USA

3. Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA

Abstract

AbstractWhile hereditary cancer syndromes have been described and studied for centuries, the completion of the human genome project fueled accelerated progress in precision medicine due to the introduction of genetic testing in the 1990s, creating avenues for tailored treatments and medical management options. However, genetic testing has not benefited everyone equitably, with nearly all of the published work based on individuals of non-Hispanic White/European ancestry. There remains a gap in knowledge regarding the prevalence, penetrance, and manifestations of common hereditary cancer syndromes in the African-American population due to significant disparities in access and uptake of genetic testing. This review summarizes the available literature on genetic testing for breast, colon, and prostate cancers in the African-American population and explores the disparities in access to genetic testing between non-Hispanic White and African-American patients. This article also addresses the barriers to genetic testing and discrepancies in the uptake of recommendations for hereditary cancer syndromes in the African-American population when compared with non-Hispanic Whites. The review offers practice implications for many healthcare providers and demonstrates gaps in the existing knowledge to be addressed in future studies to help eliminate the persisting health disparities faced by the African-American population.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference56 articles.

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3. Comparison of breast cancer molecular features and survival by African and European Ancestry in The Cancer Genome Atlas.;Huo;JAMA Oncol.,2017

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