Breast Nurse Intervention to Improve Adherence to Endocrine Therapy Among Breast Cancer Patients in South Ethiopia

Author:

Getachew Sefonias12ORCID,Addissie Adamu12,Seife Edom3,Wakuma Tariku4,Unverzagt Susanne5,Jemal Ahmedin6ORCID,Taylor Lesley7,Wienke Andreas2,Kantelhardt Eva J28ORCID

Affiliation:

1. Department of Preventive Medicine, School of Public Health, Addis Ababa University , Ethiopia

2. Institute of Medical Epidemiology, Biometrics and Informatics, Martin-Luther-University (Saale) , Halle , Germany

3. Radiotherapy Center, Tikur Anbessa Hospital, Addis Ababa University , Ethiopia

4. Department of Surgery , Aira General Hospital , Ethiopia

5. Institute of General Practice and Family Medicine, Center of Health Sciences, Martin-Luther-University Halle (Saale) , Germany

6. American Cancer Society , Atlanta , Georgia , USA

7. City of Hope National Medical Center , Duarte, California USA

8. Department of Gynaecology, Martin-Luther-University , Halle , Germany

Abstract

Abstract Introduction Many women in rural Ethiopia do not receive adjuvant therapy following breast cancer surgery despite the majority being diagnosed with estrogen-receptor-positive breast cancer and tamoxifen being available in the country. We aimed to compare a breast nurse intervention to improve adherence to tamoxifen therapy for breast cancer patients. Methods and Materials The 8 hospitals were randomized to intervention and control sites. Between February 2018 and December 2019, patients with breast cancer were recruited after their initial surgery. The primary outcome of the study was adherence to tamoxifen therapy by evaluating 12-month medication-refill data with medication possession ratio (MPR) and using a simplified medication adherence scale (SMAQ) in a subjective assessment. Results A total of 162 patients were recruited (87 intervention and 75 control). Trained nurses delivered education and provided literacy material, gave additional empathetic counselling, phone call reminders, and monitoring of medication refill at the intervention hospitals. Adherence according to MPR at 12 months was high in both the intervention (90%) and control sites (79.3%) (P = .302). The SMAQ revealed that adherence at intervention sites was 70% compared with 44.8% in the control sites (P = .036) at 12 months. Persistence to therapy was found to be 91.2% in the intervention and 77.8% in the control sites during the one-year period (P = .010). Conclusion Breast nurses can improve cost-effective endocrine therapy adherence at peripheral hospitals in low-resource settings. We recommend such task sharing to overcome the shortage of oncologists and distances to central cancer centers.

Funder

Susan Komen Foundation

Graduate Training in Disparities Research

Komen

Martin-Luther-University

Halle (Saale) Germany

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Reference60 articles.

1. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Sung;CA: Cancer J Clin,2021

2. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries;Bray;CA: Cancer J Clin,2018

3. Breast cancer in low-middle income countries: abnormality in splicing and lack of targeted treatment options;Francies;Am J Cancer Res,2020

4. Breast cancer survival in sub-Saharan Africa by age, stage at diagnosis and human development index: A population-based registry study;Joko-Fru;Int J Cancer,2020

5. Types of cancers diagnosed and the preference of families of adult patients with cancer about disclosing diagnosis to the patients;Abebe;Ethiop J Health Sci,2017

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3