The Essentials of Multiomics

Author:

Marshall John L1ORCID,Peshkin Beth N2ORCID,Yoshino Takayuki3ORCID,Vowinckel Jakob4ORCID,Danielsen Håvard E5ORCID,Melino Gerry6ORCID,Tsamardinos Ioannis7ORCID,Haudenschild Christian8,Kerr David J9,Sampaio Carlos10ORCID,Rha Sun Young11ORCID,FitzGerald Kevin T12ORCID,Holland Eric C13ORCID,Gallagher David14ORCID,Garcia-Foncillas Jesus15ORCID,Juhl Hartmut16ORCID

Affiliation:

1. Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA

2. Georgetown University, Lombardi Comprehensive Cancer Center, Washington, DC, USA

3. National Cancer Center Hospital East, Chiba, Japan

4. Biognosys AG, Schlieren, Switzerland

5. Institute for Cancer Genetics and Informatics, Oslo University Hospital, Radiumhospitalet, Montebello, Oslo, Norway

6. Department of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy

7. JADBio Gnosis DA, N. Plastira 100, Science and Technology Park of Crete and Institute of Applied and Computational Mathematics, Foundation for Research and Technology Hellas, Heraklion, GR, Greece

8. Personalis, Inc., Menlo Park, CA, USA

9. Nuffield Division of Clinical and Laboratory Sciences, Level 4, Academic Block, John Radcliffe Infirmary, Headington, Oxford, UK

10. Clinica AMO, Rio Vermelho, Salvador-BA, Brasil

11. Yonsei Cancer Center, Yonsei University College of Medicine, Seodaemun-Ku, Seoul, Korea

12. Department of Medical Humanities in the School of Medicine, Creighton University, Omaha, NE, USA

13. Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

14. St. James’s Hospital/Trinity College Dublin, St. Raphael’s House, Dublin, Ireland

15. Cancer Institute, Fundacion Jimenez Diaz University Hospital, Autonomous University, Madrid, Spain

16. Indivumed GmbH, Hamburg, Germany

Abstract

AbstractWithin the last decade, the science of molecular testing has evolved from single gene and single protein analysis to broad molecular profiling as a standard of care, quickly transitioning from research to practice. Terms such as genomics, transcriptomics, proteomics, circulating omics, and artificial intelligence are now commonplace, and this rapid evolution has left us with a significant knowledge gap within the medical community. In this paper, we attempt to bridge that gap and prepare the physician in oncology for multiomics, a group of technologies that have gone from looming on the horizon to become a clinical reality. The era of multiomics is here, and we must prepare ourselves for this exciting new age of cancer medicine.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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