Large Cell Neuroendocrine Prostate Cancer: Large Is Not Small

Author:

Serritella Anthony V1ORCID,Beltran Himisha2ORCID,Lotan Tamara L3,VanderWeele David J1,Karzai Fatima4,Madan Ravi A4ORCID,Hussain Maha1ORCID

Affiliation:

1. Robert H. Lurie Comprehensive Cancer Center; Northwestern University Feinberg School of Medicine , Chicago, IL , USA

2. Dana-Farber Cancer Institute, Harvard Medical School , Boston, MA , USA

3. Department of Pathology, Department of Urology, Department of Oncology, Johns Hopkins University School of Medicine , Baltimore, MD , USA

4. Genitourinary Malignancies Branch Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, MD , USA

Abstract

Neuroendocrine prostate cancer is complex, comprising a wide spectrum of phenotypes, which has led to very different entities being inappropriately lumped together or assumed to behave like more common entities. Elucidating subtle differences is critical for treatment decision making, as this commentary describes.

Publisher

Oxford University Press (OUP)

Reference41 articles.

1. Neuroendocrine prostate cancer: subtypes, biology,;Aggarwal,2014

2. Clinical and genomic characterization of treatment-emergent small-cell neuroendocrine prostate cancer: a multi-institutional prospective study;Aggarwal,2018

3. Deciphering the enigma of neuroendocrine prostate cancer;Karzai,2022

4. Therapy considerations in neuroendocrine prostate cancer: what next;Beltran,2021

5. Clinical features of neuroendocrine prostate cancer;Conteduca,2019

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