1. School of Mathematics, Shandong University , Jinan, 250100 , China
2. Department of Biomedical Informatics , College of Medicine, , Columbus, OH, 43210 , USA
3. The Ohio State University , College of Medicine, , Columbus, OH, 43210 , USA
4. Pelotonia Institute for Immuno-Oncology , The James Comprehensive Cancer Center, , Columbus, OH, 43210 , USA
5. The Ohio State University , The James Comprehensive Cancer Center, , Columbus, OH, 43210 , USA