The influence of electrode types to the visually induced gamma oscillations in mouse primary visual cortex

Author:

Deng Haoran12,Cui Yan12,Liu Haolun12,Zhang Guizhi12,Chai Xiaoqian12,Yang Xiaotong3,Gong Qiang12,Yu Shuang12,Guo Daqing12,Xia Yang12,Yao Dezhong12456,Chen Ke1245

Affiliation:

1. Sichuan Provincial Key Laboratory for Human Disease Gene Study and the Center for Medical Genetics , Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, , No. 2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu, Sichuan 611731 , P.R. China

2. University of Electronic Science and Technology of China , Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, , No. 2006, Xiyuan Ave, West Hi-Tech Zone, Chengdu, Sichuan 611731 , P.R. China

3. Department of Cardiology, Guizhou Provincial People's Hospital , 83 Zhongshan East Road, Nanming District, Guiyang, Guizhou, 550002 , P.R. China

4. Research Unit for Blindness Prevention , Chinese Academy of Medical Sciences (2019RU026), , 32 West Second Section of First Ring Road, Chengdu, Sichuan, 610072 , P.R. China

5. Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital , Chinese Academy of Medical Sciences (2019RU026), , 32 West Second Section of First Ring Road, Chengdu, Sichuan, 610072 , P.R. China

6. Research Unit of NeuroInformation , Chinese Academy of Medical Sciences, 2019RU035, Xiyuan road 2006, Chengdu 611731 , China

Abstract

Abstract The local field potential (LFP) is an extracellular electrical signal associated with neural ensemble input and dendritic signaling. Previous studies have linked gamma band oscillations of the LFP in cortical circuits to sensory stimuli encoding, attention, memory, and perception. Inconsistent results regarding gamma tuning for visual features were reported, but it remains unclear whether these discrepancies are due to variations in electrode properties. Specifically, the surface area and impedance of the electrode are important characteristics in LFP recording. To comprehensively address these issues, we conducted an electrophysiological study in the V1 region of lightly anesthetized mice using two types of electrodes: one with higher impedance (1 MΩ) and a sharp tip (10 μm), while the other had lower impedance (100 KΩ) but a thicker tip (200 μm). Our findings demonstrate that gamma oscillations acquired by sharp-tip electrodes were significantly stronger than those obtained from thick-tip electrodes. Regarding size tuning, most gamma power exhibited surround suppression at larger gratings when recorded from sharp-tip electrodes. However, the majority showed enhanced gamma power at larger gratings when recorded from thick-tip electrodes. Therefore, our study suggests that microelectrode parameters play a significant role in accurately recording gamma oscillations and responsive tuning to sensory stimuli.

Funder

National Natural Science Foundation of China

Sichuan Science and Technology Program

CAMS Innovation Fund for Medical Sciences

Publisher

Oxford University Press (OUP)

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