The gradient model of brain organization in decisions involving “empathy for pain”

Author:

Labek Karin1,Sittenberger Elisa2,Kienhöfer Valerie12ORCID,Rabl Luna12ORCID,Messina Irene23ORCID,Schurz Matthias14ORCID,Stingl Julia C5ORCID,Viviani Roberto12ORCID

Affiliation:

1. University of Innsbruck Institute of Psychology, , Universitätsstraße 5-7, 6020 Innsbruck , Austria

2. University of Ulm Psychiatry and Psychotherapy Clinic III, , Leimgrubenweg 12, 89075 Ulm , Germany

3. Scienze e Tecniche Psicologiche,Universitas Mercatorum , Piazza Mattei 10, 00186 Rome , Italy

4. University of Innsbruck Digital Science Center (DiSC), , Innrain 15, 6020 Innsbruck , Austria

5. University Clinic Aachen Clinical Pharmacology, , Wendlingweg 2, 52074 Aachen , Germany

Abstract

AbstractInfluential models of cortical organization propose a close relationship between heteromodal association areas and highly connected hubs in the default mode network. The “gradient model” of cortical organization proposes a close relationship between these areas and highly connected hubs in the default mode network, a set of cortical areas deactivated by demanding tasks. Here, we used a decision-making task and representational similarity analysis with classic “empathy for pain” stimuli to probe the relationship between high-level representations of imminent pain in others and these areas. High-level representations were colocalized with task deactivations or the transitions from activations to deactivations. These loci belonged to 2 groups: those that loaded on the high end of the principal cortical gradient and were associated by meta-analytic decoding with the default mode network, and those that appeared to accompany functional repurposing of somatosensory cortex in the presence of visual stimuli. These findings suggest that task deactivations may set out cortical areas that host high-level representations. We anticipate that an increased understanding of the cortical correlates of high-level representations may improve neurobiological models of social interactions and psychopathology.

Funder

University of Innsbruck

Austrian Science Fund

Federal Institute for Drugs and Medical Devices

Publisher

Oxford University Press (OUP)

Subject

Cellular and Molecular Neuroscience,Cognitive Neuroscience

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